-
Preparing edoxaban tosylate in formulating pharmaceutical composition, comprises reacting edoxaban with para-toluene sulfonic acid in alcohol solvent, and isolating edoxaban tosylate substantially free of N-oxide impurity
2023-09-25
-
New stable isavuconazonium sulfate for preparing pharmaceutical composition
2023-09-23
-
Preparing abrocitinib for treating moderate-to-severe atopic dermatitis, comprises reacting methylamino cyclobutane compound with acid, reacting acid salt of compound with base, reacting protected 7H-pyrrolo[2,3-d]pyrimidine compound with propane sulfonyl halide, and converting obtained compound
2023-09-14
-
Preparing ritlecitinib used for treating severe alopecia areata, involves reacting 7H-pyrrole[2,3-d]pyrimidine derivative with piperidine derivative followed by deprotecting the amine protected group, converting (6-methylpiperidin-3-yl)-7H-pyrrolo [2,3-d]pyrimidin-4-amine into ritlecitinib
2023-09-07
-
Preparing gemigliptin for treating type 2 diabetes by reacting amine compound with difluoro compound, deprotecting tert-butyl (S)-(4-(2,4-bis(trifluoromethyl)-dihydropyrido[3,4-d]pyrimidin-7(6H)-yl)-1-(5,5-difluoro-2-oxopiperidin-1-yl)-4- oxobutan-2-yl)carbamate to obtain gemigliptin
2023-09-05
-
Preparing 7-chloro-6-fluoro-1-[4-methyl-2-(propan-2-yl)pyridin-3-yl]-1H,2H,3H,4H-pyrido[2,3-d]pyrimidine-2,4-dione, by e.g. cyclizing substituted heterocyclic compounds to provide 7-chloro-6-fluoro-1-[4-methyl-2-(propan-2-yl)pyridin-3-yl]-1H,2H,3H,4H-pyrido[2,3-d]pyrimidine-2,4-dione, and resolution
2023-08-28
-
Preparing (R)-1-(2-chlorophenyl)ethane-1,2-diol (II) that is used for preparing Cenobamate i.e. antiepileptic drug, which can be used for treating disorders of e.g. CNS, anxiety, depression, convulsion, epilepsy, comprises reducing (2R)-(2-chlorophenyl)(hydroxy)acetic acid with reducing agent
2023-08-24
-
Preparing methyl 2-[4-(2-chloroethyl)-phenyl]-2-methyl-propionate compound used for preparing Bilastine, involves reacting 1-[4-(2-chloroethyl)-phenyl]-2- methyl-propan-1-one compound with N-chlorosuccinamide to provide 2-chloro-1-[4-(2-chloroethyl)-phenyl]-2-methyl-propan-1-one
2023-08-17
-
Preparing tapinarof in treatment of plaque psoriasis, comprises dealkylating stilbene derivative, and using dealkylating agent in presence of metal catalyst to provide tapinarof
2023-07-27
