| Composition in the form of airgel microparticles based on chitosan used as nasal drug delivery systems, in which the microparticles have spherical shape with a specified surface area, porosity and aerodynamic diameter | |
| 2022-05-18 | |
| 专利权人 | FEDERAL STATE BUDGETARY EDUCATIONAL (BUDG-Non-standard) |
| 申请日期 | 2022-05-18 |
| 专利号 | RU2022113331-A |
| 成果简介 | NOVELTY - Composition in the form of airgel microparticles based on chitosan, where the microparticles have a spherical shape with a specific surface area of 200-600 m2/g, porosity 96-99% and aerodynamic diameter of 40-100 μ m. USE - The composition is useful as nasal drug delivery systems. No biological data given. ADVANTAGE - None given. DETAILED DESCRIPTION - An INDEPENDENT CLAIM is also included for producing the composition comprising (a) weighing portion of dry chitosan and dissolving in 0.1-1 M solution of acetic acid with continuous stirring, brought to a concentration of 1-5 wt.%, preparing a crosslinking agent solution in the form of a concentrated alkali solution of 0.1-4 M, using a spray nozzles spraying a solution of chitosan in acetic acid into a crosslinking agent solution in the form of fine droplets to form fine drops spray, keeping the gel microparticles formed as a result of spraying for at least 12 hours in a crosslinking agent solution, after which the repeatedly washing gel microparticles from the crosslinking agent solution using distilled water to achieve a neutral pH 7, then replacing the water with isopropyl alcohol in several stages, at each of which the concentration of isopropyl alcohol is gradually increased in steps of 30-50-70-90-99.8 wt.%, and, the last step is repeated twice and then supercritical drying is carried out for 6 hours at a pressure of 120-140 atm, 40° C and a carbon dioxide flow rate of 0.2 kg/h. |
| IPC 分类号 | A61K-009/14 ; A61K-009/72 ; A61P-043/00 |
| 国家 | 俄罗斯 |
| 专业领域 | 医药卫生 |
| 语种 | 英语 |
| 成果类型 | 专利 |
| 文献类型 | 科技成果 |
| 条目标识符 | http://119.78.100.226:8889/handle/3KE4DYBR/22570 |
| 专题 | 中国科学院新疆生态与地理研究所 |
| 作者单位 | FEDERAL STATE BUDGETARY EDUCATIONAL (BUDG-Non-standard) |
| 推荐引用方式 GB/T 7714 | MENSHUTINA N V,LOVSKAYA D D,TSYGANKOV P YU,et al. Composition in the form of airgel microparticles based on chitosan used as nasal drug delivery systems, in which the microparticles have spherical shape with a specified surface area, porosity and aerodynamic diameter. RU2022113331-A[P]. 2022. |
| 条目包含的文件 | 条目无相关文件。 | |||||
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。
修改评论