| PHARMACEUTICAL COMPOSITION BASED ON PROTEIN AEROGELS FOR USE AS INTRANASAL SPRAYS AND A METHOD OF ITS PRODUCTION | |
| 2022-05-18 | |
| 专利权人 | FEDERAL STATE BUDGETARY EDUCATIONAL (BUDG-Non-standard) |
| 申请日期 | 2022-05-18 |
| 专利号 | RU2801351-C1 |
| 成果简介 | NOVELTY - Invention is intended to create pharmaceutical compositions based on protein aerogel. To obtain a protein aerogel, a dry protein sample is dissolved in deionized water and the solution is kept for 24 hours at a temperature of 5°C for complete dissolution of the protein. Then, with constant stirring, the solution is adjusted to pH=2–12 with hydrochloric acid and/or sodium hydroxide. Vegetable oil preheated in a water bath to 80°C is introduced into the resulting solution with vigorous stirring. After that, the formed gel particles are kept at room temperature, washed with distilled water, then with a water-alcohol solution in six stages, at each of which the gel particles are placed in a water-alcohol mixture with an exposure of two hours, and the alcohol concentration in the water-alcohol the mixture is increased sequentially at each stage with a step of 10–30–50–70–90–99.8 wt.%. The last stage is repeated twice, after which supercritical drying is carried out for 6 hours at a temperature of 40°C, pressure of 120 atm and carbon dioxide consumption of 0.2 kg/h. As a result, a protein aerogel is obtained in the form of particles ranging in size from 50 to 1,500 μm with a specific surface area of 60–500 m2/g and a porosity of 90–99%. USE - Pharmaceutical industry and medicine. ADVANTAGE - Use of the invention provides for the production of a protein aerogel that can be effectively used as part of pharmaceutical compositions in the form of intranasal sprays with an improved release profile. 1 cl, 3 dwg, 4 ex |
| IPC 分类号 | A61K-009/51 ; A61P-043/00 |
| 国家 | 俄罗斯 |
| 专业领域 | 医药卫生 |
| 语种 | 英语 |
| 成果类型 | 专利 |
| 文献类型 | 科技成果 |
| 条目标识符 | http://119.78.100.226:8889/handle/3KE4DYBR/22569 |
| 专题 | 中国科学院新疆生态与地理研究所 |
| 作者单位 | FEDERAL STATE BUDGETARY EDUCATIONAL (BUDG-Non-standard) |
| 推荐引用方式 GB/T 7714 | MENSHUTINA N V,LOVSKAYA D D,TSYGANKOV P YU,et al. PHARMACEUTICAL COMPOSITION BASED ON PROTEIN AEROGELS FOR USE AS INTRANASAL SPRAYS AND A METHOD OF ITS PRODUCTION. RU2801351-C1[P]. 2022. |
| 条目包含的文件 | 条目无相关文件。 | |||||
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