| COMBINED NANOPARTICLES BASED ON AMPHIPHILIC COPOLYMERS OF N-VINYLPYRROLIDONE FOR COMBINED TARGETED DRUG DELIVERY | |
| 2023-04-20 | |
| 专利权人 | KUSKOV A N (KUSK-Individual) ; YAGOLOVICH A V (YAGO-Individual) ; MANEBIO LLC (MANE-Non-standard) |
| 申请日期 | 2023-04-20 |
| 专利号 | RU2830606-C2 |
| 成果简介 | NOVELTY - Invention relates to chemistry, biotechnology and pharmaceutics, specifically to a nanoparticle for delivering anticancer drugs. Disclosed nanoparticle is a micelle consisting of amphiphilic polymers with number-average molecular weight of 1–30 kDa of general formula C4H2NO2-(--M--)-(CO)-R and Cl-(--M--)-(CO)-R, where (--M--) is hydrophilic part of N-vinylpyrrolidone monomers, and R is a hydrophobic part with the structure -(C8-19-alkyl)-CH3, wherein one of the anticancer drugs is low-molecular and is located in the nucleus of the nanoparticle, and the other anti-tumour preparation is conjugated with the surface of the nanoparticle and is a target receptor-specific substance of a peptide nature, which is a variant of the cytokine TRAIL, selected from DR5-B with an amino acid sequence homologous to at least 90% of the sequence SEQ ID NO: 1, and DR5-B-iRGD with an amino acid sequence homologous to at least 90% of the sequence SEQ ID NO: 2. USE - Chemistry; biotechnology; pharmaceutics. ADVANTAGE - Invention provides novel combined micellar nanoparticles characterized by improved pharmacokinetic properties, enhanced therapeutic effect and controlled release of the preparation from the hydrophobic core. 7 cl, 5 dwg, 7 ex |
| IPC 分类号 | A61K-031/4965 ; A61K-031/69 ; A61K-038/19 ; A61K-047/50 ; A61K-047/69 ; A61K-009/14 ; A61P-035/00 ; B82B-001/00 ; B82Y-005/00 |
| 国家 | 俄罗斯 |
| 专业领域 | 生物科学 |
| 语种 | 英语 |
| 成果类型 | 专利 |
| 文献类型 | 科技成果 |
| 条目标识符 | http://119.78.100.226:8889/handle/3KE4DYBR/21992 |
| 专题 | 中国科学院新疆生态与地理研究所 |
| 作者单位 | 1.KUSKOV A N (KUSK-Individual) 2.YAGOLOVICH A V (YAGO-Individual) 3.MANEBIO LLC (MANE-Non-standard) |
| 推荐引用方式 GB/T 7714 | YAGOLOVICH A V,KUSKOV A N,KULIKOV P P,et al. COMBINED NANOPARTICLES BASED ON AMPHIPHILIC COPOLYMERS OF N-VINYLPYRROLIDONE FOR COMBINED TARGETED DRUG DELIVERY. RU2830606-C2[P]. 2023. |
| 条目包含的文件 | 条目无相关文件。 | |||||
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