Predicting decrease in estimated glomerular filtration rate (eGFR) in 12 months after PTE in patients with PHPT, comprises determining set of diagnostically significant indicators i.e. gender and age at the time of surgery
	ELFIMOVA A R; EREMKINA A K; REBROVA O I; KOVALEVA E V; MOKRYSHEVA N G
	2023-05-02
专利权人	FEDERAL STATE BUDGETARY INST (FSBI-C)
申请日期	2023-05-02
专利号	RU2023111351-A
成果简介	NOVELTY - Predicting the decrease in estimated glomerular filtration rate (eGFR) in 12 months after parathyroidectomy (PTE) in patients with primary hyperparathyroidism (PHPT), comprises determining a set of diagnostically significant indicators i.e. gender; age at the time of surgery [years]; body mass index [kg/m2]; laboratory parameters before PTE-parathyroid hormone [pg/ml], ionized calcium [mmol/l], phosphorus [mmol/l], alkaline phosphatase [U/l], total cholesterol [mmol/l], urea [mmol/l], eGFR [ml/min/1.73m2]; instrumental parameters before PTE- bone mineral density SD, diastolic blood pressure [mm Hg.Art.]; anamnesis data before PTE-taking angiotensin-converting enzyme inhibitors for ≥ 6 months before surgery [yes/no], taking angiotensin II receptor blockers for ≥ 6 months before surgery [yes/no], presence of nephrolithiasis [yes/no], duration of nephrolithiasis [months]; and drug therapy parameters before PTE-preoperative administration of at least 1 dose of cinacalcet. USE - The method is useful for predicting decrease in estimated glomerular filtration rate (eGFR) in 12 months after PTE in patients with PHPT. ADVANTAGE - The method can predict decrease in estimated glomerular filtration rate (eGFR). DETAILED DESCRIPTION - Predicting the decrease in estimated glomerular filtration rate (eGFR) in 12 months after parathyroidectomy (PTE) in patients with primary hyperparathyroidism (PHPT), comprises determining a set of diagnostically significant indicators i.e. gender; age at the time of surgery [years]; body mass index [kg/m2]; laboratory parameters before parathyroid extract (PTE)-parathyroid hormone [pg/ml], ionized calcium [mmol/l], phosphorus [mmol/l], alkaline phosphatase [U/l], total cholesterol [mmol/l], urea [mmol/l], eGFR [ml/min/1.73m2]; instrumental parameters before PTE- bone mineral density SD, diastolic blood pressure [mm Hg.Art.]; anamnesis data before PTE-taking angiotensin-converting enzyme inhibitors for ≥ 6 months before surgery [yes/no], taking angiotensin II receptor blockers for ≥ 6 months before surgery [yes/no], presence of nephrolithiasis [yes/no], duration of nephrolithiasis [months]; drug therapy parameters before PTE-preoperative administration of at least 1 dose of cinacalcet not more than 2 days before surgery [yes/no], preoperative administration of cholecalciferol more than 1 week before surgery [yes/no]; anamnesis data after PTE-postoperative hypocalcemia [yes/no]; histological diagnosis based on examination of surgical material of the parathyroid gland (PTG)-adenoma or hyperplasia of the PTG [yes/no]; parameters of drug therapy after PTE - dose of alfacalcidol [mcg/day], dose of calcium preparations [mg/day], dose of cholecalciferol [IU/week], after which the measured parameters are processed using at least one classification model trained to determine the decrease in eGFR 12 months after the PTE. A random forest type model is used as the classification models.
IPC 分类号	A61B-005/02 ; A61B-005/107 ; A61B-006/00 ; G01N-033/50 ; G01N-033/62 ; G01N-033/78 ; G01N-033/92 ; G16H-050/30
国家	俄罗斯
专业领域	生物科学
语种	英语
成果类型	专利
文献类型	科技成果
条目标识符	http://119.78.100.226:8889/handle/3KE4DYBR/21939
专题	中国科学院新疆生态与地理研究所
作者单位	FEDERAL STATE BUDGETARY INST (FSBI-C)
推荐引用方式 GB/T 7714	ELFIMOVA A R,EREMKINA A K,REBROVA O I,et al. Predicting decrease in estimated glomerular filtration rate (eGFR) in 12 months after PTE in patients with PHPT, comprises determining set of diagnostically significant indicators i.e. gender and age at the time of surgery. RU2023111351-A[P]. 2023.

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