Preparing bis ethylenedioxy pregna diene in continuous flow reactor involves dissolving bis ethylenedioxy-pregna diene derivative in organic solvent and passing through continuous flow reactor having filtered light beam
	RAMDAS P L; GOVIND A S; GANGADHAR T R; MRIGANKA P C; ABHIJIT R; KESHAV G M
	2023-05-09
专利权人	EMCURE PHARM LTD (EMCU-Non-standard)
申请日期	2023-05-09
专利号	IN202321032650-A
成果简介	NOVELTY - Preparing 9β,10α 3,20-bis(ethylenedioxy)-pregna-5,7-diene (III) in a continuous flow reactor involves dissolving 9α,10β-3,20-bis(ethylenedioxy)-pregna-5,7-diene derivative (I) in an organic solvent and passing it through a continuous flow reactor having a filtered light beam at the rate of 5-60 ml per minute. The derivative (I) undergoes a photochemical reaction and gets converted into 3,20-bis(ethylenedioxy), 6E/Z-9,10-seco-pregna-5(10),6,8-triene intermediate (II), which gets converted into compound (III), followed by concentration of the reaction mixture and isolation from a mixture of acetonitrile and methanol. USE - Method for preparing 9~b,10a 3,20-bis(ethylenedioxy)-pregna-5,7-diene (III) in a continuous flow reactor. ADVANTAGE - The method provides an economical, industrially viable, and environment-friendly process for the photochemical synthesis of 913,10a-pregna-5-7-diene derivatives, in a shorter duration of time, with purity complying with regulatory specifications by lowering consumption of solvents with lower amount of photochemical irradiation. DETAILED DESCRIPTION - Preparing 9~b,10a 3,20-bis(ethylenedioxy)-pregna-5,7-diene of formula (III) in a continuous flow reactor involves dissolving 9α,10β-3,20-bis(ethylenedioxy)-pregna-5,7-diene derivative of formula (I) in an organic solvent and passing it through a continuous flow reactor having a filtered light beam at the rate of 5-60 ml per minute. The derivative (I) undergoes a photochemical reaction and gets converted into 3,20-bis(ethylenedioxy), 6E/Z-9,10-seco-pregna-5(10),6,8-triene intermediate of formula (II), which gets converted into compound of formula (III), followed by concentration of the reaction mixture and isolation from a mixture of acetonitrile and methanol.
IPC 分类号	C07J-031/00 ; C07J-007/00
国家	印度
专业领域	医药卫生
语种	英语
成果类型	专利
文献类型	科技成果
条目标识符	http://119.78.100.226:8889/handle/3KE4DYBR/21901
专题	中国科学院新疆生态与地理研究所
作者单位	EMCURE PHARM LTD (EMCU-Non-standard)
推荐引用方式 GB/T 7714	RAMDAS P L,GOVIND A S,GANGADHAR T R,et al. Preparing bis ethylenedioxy pregna diene in continuous flow reactor involves dissolving bis ethylenedioxy-pregna diene derivative in organic solvent and passing through continuous flow reactor having filtered light beam. IN202321032650-A[P]. 2023.

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