Obtaining 2-(2-methoxyethyl)-3,5-dimethyl-pyridine compound comprises interaction of substituted acetylenes with nitrile and ethylaluminum dichloride in presence of titanocene dichloride catalyst
	SHAYBAKOVA M G; DILMUKHAMETOVA L K; RAMAZANOV I R; TITOVA E I
	2023-05-16
专利权人	AS RUSSIA UFA FEDERAL RES CENT (ASUF-Non-standard)
申请日期	2023-05-16
专利号	RU2023112544-A
成果简介	NOVELTY - Obtaining 2-(2-methoxyethyl)-3,5-dimethyl-pyridine compound (1) comprises interaction of substituted acetylenes with nitrile and ethylaluminum dichloride in the presence of a catalyst, characterized in that terminal acetylenes compound (Ia) are used as acetylenes, 3-methoxypropionitrile is used as nitriles, and titanocene dichloride used as a catalyst, the reaction is carried out in the presence of ethylaluminum dichloride and magnesium powder, with a molar ratio of reagents (Ia): methoxy-malononitrile: ethylaluminum dichloride: magnesium: titanocene dichloride = 10:20: (2-3):(16-20):(0.8-1.2) respectively, in tetrahydrofuran at 60° C in an argon atmosphere for 8-12 hours. USE - The method is useful for obtaining 2-(2-methoxyethyl)-3,5-dimethyl-pyridine compound. ADVANTAGE - None given. DETAILED DESCRIPTION - Obtaining 2-(2-methoxyethyl)-3,5-dimethyl-pyridine compound of formula (1) comprises interaction of substituted acetylenes with nitrile and ethylaluminum dichloride in the presence of a catalyst, characterized in that terminal acetylenes compound of formula (R1C=CH) (Ia) are used as acetylenes, 3-methoxypropionitrile is used as nitriles, and titanocene dichloride used as a catalyst, the reaction is carried out in the presence of ethylaluminum dichloride and magnesium powder, with a molar ratio of reagents (Ia): methoxy-malononitrile: ethylaluminum dichloride: magnesium: titanocene dichloride = 10:20: (2-3):(16-20):(0.8-1.2) respectively, in tetrahydrofuran at 60° C in an argon atmosphere for 8-12 hours. R1=C 2 H 1 1 , C 6 H 1 3 , or C 7 H 1 5
IPC 分类号	C07D-213/00
国家	俄罗斯
专业领域	化学化工
语种	英语
成果类型	专利
文献类型	科技成果
条目标识符	http://119.78.100.226:8889/handle/3KE4DYBR/21854
专题	中国科学院新疆生态与地理研究所
作者单位	AS RUSSIA UFA FEDERAL RES CENT (ASUF-Non-standard)
推荐引用方式 GB/T 7714	SHAYBAKOVA M G,DILMUKHAMETOVA L K,RAMAZANOV I R,et al. Obtaining 2-(2-methoxyethyl)-3,5-dimethyl-pyridine compound comprises interaction of substituted acetylenes with nitrile and ethylaluminum dichloride in presence of titanocene dichloride catalyst. RU2023112544-A[P]. 2023.

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