METHOD FOR PREPARING SOLID FORM OF DRUG TAMERON IN FORM OF ENTERIC CAPSULES
	ERMAKOV A M; ERMAKOVA O N; TSARKOV A N; TSARKOVA E A
	2023-05-29
专利权人	EXPERT RES AUTONOMOUS NON-PROFIT ORG INS (EXPE-Non-standard)
申请日期	2023-05-29
专利号	RU2827329-C1; RU2827329-C9
成果简介	NOVELTY - Invention relates to pharmacology and pharmaceutical industry and concerns a method for preparing a solid dosage form of Tameron in the form of solid enteric capsules filled with granules or modified release granules containing an active pharmaceutical substance sodium aminodihydrophthalazinedione. Granules for filling have the following versions of composition. Composition 1, wt.%: sodium aminodihydrophthalazinedione: 25–35; hydroxypropyl cellulose: 1–10, or hydroxymethyl cellulose: 1–10, or hydroxypropyl methylcellulose: 1–10; colloidal silicon dioxide: 1; magnesium stearate: 1; mannitol: up to 100 or sorbitol: up to 100. Composition 2: wt.%: sodium aminodihydrophthalazinedione: 25–35; hydroxypropyl cellulose: 1–10, or hydroxymethyl cellulose: 1–10, or hydroxypropyl methylcellulose: 1–10; polyvinylpyrrolidone: 1–5; dextran: 3–25, or sodium alginate: 3–25, or chitosan: 3–25; colloidal silicon dioxide: 1%; magnesium stearate: 1%; mannitol: up to 100% or sorbitol: up to 100%. Technical result consists in preparing a solid form of a drug preparation Tameron based on sodium aminodihydrophthalazinedione in the form of solid enteric capsules, which nucleus is composed of granules or granules with modified release, which provides the possibility of using various technologies of capsule filling by means of manual, semi-automatic and automatic methods. USE - Medicine; pharmaceutics. ADVANTAGE - Ease of use of the preparation Tameron, manufacturability, preservation of biological activity and physical properties of the preparation, storage stability, high bioavailability, safety of use and efficacy of releasing the medicinal substance of the given dosage form. 1 cl, 2 tbl, 1 ex
IPC 分类号	A61K-031/502 ; A61K-009/52
国家	俄罗斯
专业领域	生物科学
语种	英语
成果类型	专利
文献类型	科技成果
条目标识符	http://119.78.100.226:8889/handle/3KE4DYBR/21753
专题	中国科学院新疆生态与地理研究所
作者单位	EXPERT RES AUTONOMOUS NON-PROFIT ORG INS (EXPE-Non-standard)
推荐引用方式 GB/T 7714	ERMAKOV A M,ERMAKOVA O N,TSARKOV A N,et al. METHOD FOR PREPARING SOLID FORM OF DRUG TAMERON IN FORM OF ENTERIC CAPSULES. RU2827329-C1; RU2827329-C9[P]. 2023.

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