Assessing risk of developing vincristine polyneuropathy in children by isolating genomic DNA from leukocytes of peripheral blood of pediatric patient and genotyping single-nucleotide variant rs924607 in promoter region of CEP72 gene
	KOVTUN O P; KORIAKINA O V; TSAUR G A; FECHINA L G; PERMIKIN ZH V
	2023-06-09
专利权人	UNIV URAL STATE MEDICAL (UYUR-Soviet Institute)
申请日期	2023-06-09
专利号	RU2023115384-A; RU2833397-C2
成果简介	NOVELTY - Assessing the risk of developing vincristine polyneuropathy in children with acute lymphoblastic leukemia, comprises isolating genomic DNA from leukocytes of the peripheral blood of a pediatric patient and genotyping of the single-nucleotide variant rs924607 in the promoter region of the CEP72 gene is performed by real-time PCR (RT-PCR), then evaluating the results using the allelic discrimination method, and if the allele (T) is identified, determining a high-risk group for the development of peripheral polyneuropathy in children with acute lymphoblastic leukemia receiving vincristine. USE - The method is useful for assessing the risk of developing vincristine polyneuropathy in children with acute lymphoblastic leukemia. ADVANTAGE - None given.
IPC 分类号	C12Q-001/6806 ; C12Q-001/6827 ; C12Q-001/6858 ; C12Q-001/686 ; C12Q-001/6883 ; G01N-033/58
国家	俄罗斯
专业领域	生物科学
语种	英语
成果类型	专利
文献类型	科技成果
条目标识符	http://119.78.100.226:8889/handle/3KE4DYBR/21657
专题	中国科学院新疆生态与地理研究所
作者单位	UNIV URAL STATE MEDICAL (UYUR-Soviet Institute)
推荐引用方式 GB/T 7714	KOVTUN O P,KORIAKINA O V,TSAUR G A,et al. Assessing risk of developing vincristine polyneuropathy in children by isolating genomic DNA from leukocytes of peripheral blood of pediatric patient and genotyping single-nucleotide variant rs924607 in promoter region of CEP72 gene. RU2023115384-A; RU2833397-C2[P]. 2023.

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