| METHOD OF INHIBITING GROWTH OF TUMOR CELLS USING MAGNETIC RESONANCE HYPERTHERMIA AND APTAMER-TARGETED MAGNETIC NANOPARTICLES | |
| 2023-07-11 | |
| 专利权人 | AS SIBE KRASNOYARSK SCI CENT (ASIK-Non-standard) |
| 申请日期 | 2023-07-11 |
| 专利号 | RU2812581-C1 |
| 成果简介 | NOVELTY - Invention is intended to inhibit the growth of tumour cells, both the main and a concomitant method of therapy. A method is presented for inhibiting the growth of tumour cells using magnetic resonance hyperthermia and aptamer-targeted magnetic nanoparticles, characterized by the fact that magnetic nanoparticles (MNs) having a modified shell of silicon oxide Fe3O4@SiO2@NH 2 with conjugated aptamers are used as thermal mediators , complementary to Ehrlich ascites carcinoma, the MN is exposed to a constant magnetic and ultra-high-frequency electromagnetic field (microwave), the fields used are orthogonal, when the frequency of precession of the magnetization vector around the constant magnetic field and the frequency of the microwave field coincide, the phenomenon of ferromagnetic resonance (FMR) occurs, resulting in heating magnetic nanoparticles due to absorption of microwave field energy. USE - Biophysics; medicine; experimental oncology. ADVANTAGE - Invention provides increased binding of silicon-modified magnetic nanoparticles and tumour cells, increased heating efficiency due to the effect of ferromagnetic resonance in magnetic nanoparticles, which leads to the initiation of apoptosis processes. 1 cl, 3 dwg |
| IPC 分类号 | A61K-047/00 ; G01N-022/00 |
| 国家 | 俄罗斯 |
| 专业领域 | 医药卫生 |
| 语种 | 英语 |
| 成果类型 | 专利 |
| 文献类型 | 科技成果 |
| 条目标识符 | http://119.78.100.226:8889/handle/3KE4DYBR/21333 |
| 专题 | 中国科学院新疆生态与地理研究所 |
| 作者单位 | AS SIBE KRASNOYARSK SCI CENT (ASIK-Non-standard) |
| 推荐引用方式 GB/T 7714 | STOLYAR S V,LI O A,VELIKANOV D A,et al. METHOD OF INHIBITING GROWTH OF TUMOR CELLS USING MAGNETIC RESONANCE HYPERTHERMIA AND APTAMER-TARGETED MAGNETIC NANOPARTICLES. RU2812581-C1[P]. 2023. |
| 条目包含的文件 | 条目无相关文件。 | |||||
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