Preparing peri-implant osteogenic potential exhibiting insulin-like growth factor-1 loaded neutral poly (lactic-co-glycolic acid) nanoparticles, involves emulsification of organic phase into aqueous phase, preparing insulin-like growth factor-1 loaded neutral nanoparticles by centrifuging emulsion
	KANDASAMY R; KRISHNASWAMI V; VIJAYARAGHAVALU S; VAIDYANATHAN A K; RAZA F B
	2023-07-12
专利权人	SRI RAMACHANDRA HIGHER EDUCATION & RES (SRIR-Non-standard)
申请日期	2023-07-12
专利号	IN202341046965-A
成果简介	NOVELTY - Preparing peri-implant osteogenic potential exhibiting insulin-like growth factor-1 (IGF-1) loaded neutral poly (lactic-co-glycolic acid) (PLGA) nanoparticles involves (a) preparing organic phase by dissolving PLGA in acetone and aqueous IGF-1 by stirring to form organic phase; (b) preparing aqueous phase by mixing polyvinyl alcohol (PVA) in water by stirring to form aqueous phase; (c) preparing water in oil-in-water emulsion by emulsification of organic phase drop by drop into aqueous phase under stirring to form a water-in-oil emulsion; (d) preparing IGF-1 loaded neutral PLGA nanoparticles by centrifuging the water-in-oil-in-water emulsion to form pellet I, suspending supernatant I and pellet I with MiliQ water, centrifuging to form pellet II and supernatant II, adding pellet II to sucrose solution followed by placing in freezer and freeze-drying in lyophilizer and lyophilizing to form IGF-1 loaded neutral PLGA nanoparticles, and storing, where the supernatant I and II are discarded. USE - Method for preparing peri-implant osteogenic potential exhibiting insulin-like growth factor-1 (IGF-1) loaded neutral poly (lactic-co-glycolic acid) (PLGA) nanoparticles. ADVANTAGE - The method enables enhancing encapsulation efficiency and sustained release of charged growth factor.
IPC 分类号	A61K-038/30 ; A61K-009/00 ; A61K-009/16 ; A61K-009/19 ; A61K-009/51
国家	印度
专业领域	医药卫生
语种	英语
成果类型	专利
文献类型	科技成果
条目标识符	http://119.78.100.226:8889/handle/3KE4DYBR/21326
专题	中国科学院新疆生态与地理研究所
作者单位	SRI RAMACHANDRA HIGHER EDUCATION & RES (SRIR-Non-standard)
推荐引用方式 GB/T 7714	KANDASAMY R,KRISHNASWAMI V,VIJAYARAGHAVALU S,et al. Preparing peri-implant osteogenic potential exhibiting insulin-like growth factor-1 loaded neutral poly (lactic-co-glycolic acid) nanoparticles, involves emulsification of organic phase into aqueous phase, preparing insulin-like growth factor-1 loaded neutral nanoparticles by centrifuging emulsion. IN202341046965-A[P]. 2023.

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