Formulation for improving diabetes comprises peptide nano-complexes for delivery of peptide, each nano-complex comprising cationic polymeric nanosphere comprising poly(ethylene glycol)-b poly(carbonate-{g-cationic chain}-co-lactide) polymer,negatively charged peptides that interact electrostatically
	DEEPAK C; ARUN S S; KUMAR S A; ANUPAMA M
	2023-07-14
专利权人	BIRLA INST TECHNOLOGY & SCI PILANI (BIRL-Non-standard)
申请日期	2023-07-14
专利号	IN202311047523-A
成果简介	NOVELTY - Formulation comprises peptide nano-complexes for delivery of the peptide, each nano-complex comprising (a) cationic polymeric nanosphere comprises a polyethylene carbonate-based polymer is a poly(ethylene glycol)-bpoly(carbonate-{g-cationic chain}-co-lactide) polymer, where the cationic chain is attached via free carboxylic acid groups on the polymer; and (b) negatively charged peptides that electrostatically interact with the outer surface of the cationic nanosphere at neutral pH. USE - Formulation for improving complications induced by diabetes. Test details are described but no results given. ADVANTAGE - The method is simple, easy and rapid. The nanocomplex formulation has high stability at 37 °C, high bioavailability in-vivo, has extended circulation time, high cell uptake. DETAILED DESCRIPTION - An INDEPENDENT CLAIM is included for a method of preparing a formulation comprising which involves (a) preparing blank cationic polymeric nanospheres composed of a polyethylene carbonate-based polymer being a poly(ethylene glycol)-b-poly(carbonate-{g-cationic chain}-co-lactide) polymer wherein the cationic chain is attached via free carboxylic acid groups on the polymer; and b. incubating at room temperature and neutral pH, the blank nanospheres with the peptide in a ratio of 10 : 0.01 to 1 : 100 of the blank nanospheres: the peptide, to obtain the peptide nanocomplexes.
IPC 分类号	A61K-047/60 ; A61K-049/00 ; C08L-033/06 ; C08L-071/02 ; C11D-003/37
国家	印度
专业领域	医药卫生
语种	英语
成果类型	专利
文献类型	科技成果
条目标识符	http://119.78.100.226:8889/handle/3KE4DYBR/21308
专题	中国科学院新疆生态与地理研究所
作者单位	BIRLA INST TECHNOLOGY & SCI PILANI (BIRL-Non-standard)
推荐引用方式 GB/T 7714	DEEPAK C,ARUN S S,KUMAR S A,et al. Formulation for improving diabetes comprises peptide nano-complexes for delivery of peptide, each nano-complex comprising cationic polymeric nanosphere comprising poly(ethylene glycol)-b poly(carbonate-{g-cationic chain}-co-lactide) polymer,negatively charged peptides that interact electrostatically. IN202311047523-A[P]. 2023.

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