Therapeutic composition for treating neurodegenerative diseases, comprises hydrophobic core comprising nanoparticles of rosiglitazone and vorinostat; and amphiphilic shell comprising e.g. diblock polymer consists of maleimide derivative of polyethylene glycol linked to polycaprolactone
	DEEPAK C; RAJEEV T; VIOLINA K; SARATHLAL K C
	2023-07-14
专利权人	BIRLA INST TECHNOLOGY & SCI PILANI (BIRL-Non-standard)
申请日期	2023-07-14
专利号	IN202311047524-A
成果简介	NOVELTY - Therapeutic composition comprises hydrophobic core and an amphiphilic shell; the hydrophobic core comprising nanoparticles of rosiglitazone and vorinostat; and the amphiphilic shell comprising a diblock polymer consists of a maleimide derivative of polyethylene glycol (PEG) linked to polycaprolactone (PCL); and a transactivator of transcription (TAT) peptide linked to the PEG via sulfide linkage; where the maleimide-PEG has a molecular weight of 3000-4000 KDa; the PCL has a chain length of 10-18 carbon atoms; and the TAT peptide comprising sequence of 15-20 amino acids (SEQ ID NO: not defined), given in the specification and has a sulfur containing amino acid at least one end. USE - Therapeutic composition for treating neurodegenerative diseases (claimed). No biological data given. ADVANTAGE - None given. DETAILED DESCRIPTION - An INDEPENDENT CLAIM is included for a method for preparing a therapeutic composition for neurodegenerative diseases, comprising (a) derivatizing polyethylene glycol (PEG) with maleimide to obtain maleimide PEG; (b) preparing a di-block polymer comprising maleimide PEG and polycaprolactone (PCL) by solvent evaporation; (c) coupling the di-block polymer to a transactivator of transcription (TAT) peptide via thiol coupling to obtain TAT-maleimide PEG-PCL polymer; and (d) preparing nanoparticles of the TAT-maleimide PEG-PCL polymer and encapsulating vorinostat and rosiglitazone nanoparticles in the polymer using water in oil in water (w/o/w) double emulsion solvent evaporation.
IPC 分类号	A61K-031/38 ; A61K-045/06 ; A61K-047/69 ; A61K-049/00 ; A61K-051/12 ; A61K-009/51 ; A61P-035/00 ; C07D-495/04
国家	印度
专业领域	医药卫生
语种	英语
成果类型	专利
文献类型	科技成果
条目标识符	http://119.78.100.226:8889/handle/3KE4DYBR/21307
专题	中国科学院新疆生态与地理研究所
作者单位	BIRLA INST TECHNOLOGY & SCI PILANI (BIRL-Non-standard)
推荐引用方式 GB/T 7714	DEEPAK C,RAJEEV T,VIOLINA K,et al. Therapeutic composition for treating neurodegenerative diseases, comprises hydrophobic core comprising nanoparticles of rosiglitazone and vorinostat; and amphiphilic shell comprising e.g. diblock polymer consists of maleimide derivative of polyethylene glycol linked to polycaprolactone. IN202311047524-A[P]. 2023.

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