Polymeric nano-formulation for delivery of temozolomide, comprises nano-particles, where each particle is composed of component comprising temozolomide hydrazide conjugated to amphiphilic polymer comprising polycarbonate block, polyethylene glycol block and polyester
	MITTAL A; JATYAN R; SAHEL D K; SINGH P; CHITKARA D
	2023-07-14
专利权人	INDIA MIN SCI & TECHNOLOGY DEPT BIOTECHN (DBIO-C) ; BIRLA INST TECHNOLOGY & SCI PILANI (BIRL-Non-standard)
申请日期	2023-07-14
专利号	IN202311047526-A
成果简介	NOVELTY - Polymeric nano-formulation comprises nano-particles, where each particle is composed of component 1 and a component 2 in a ratio selected from the range of 1:3-3:1. The component 1 comprises temozolomide hydrazide (TMZ-H) conjugated to an amphiphilic polymer comprising a polycarbonate block and a polyethylene glycol block. The component 2 comprises an amphiphilic polymer comprising a polyester or polycarbonate block and a polyethylene glycol block. USE - Polymeric nano-formulation for delivery of temozolomide. ADVANTAGE - The nano-formulation has higher drug loading capacity and improved stability. DETAILED DESCRIPTION - INDEPENDENT CLAIMS are included for: 1. a pharmaceutical composition, which comprises the polymeric nano-formulation of temozolomide; and 2. a method for preparing the polymeric nano-formulation of temozolomide, which involves: (a) dissolving component 1 and component 2 in dichloromethane: ethanol of ratio 3:1 and subjecting the mixture to the thin film hydration process resulting in the formation of a thin film of a hybrid composition of components 1 and 2; (b) purging the thin film with dried nitrogen gas for 30-60 minutes and redispersing the thin film using a dispersive medium being phosphate-buffered saline to yield a dispersion mixture; and (c) probe-sonicating the dispersion mixture for 15-30 seconds at 20% amplitude under ice-cold conditions, followed by centrifugation at 10,000-15,000 revolutions per minute (rpm) for 15 5-15 minutes, resulting in a supernatant comprising the nano-particle formulation of temozolomide.
IPC 分类号	A61K-031/4188 ; A61K-031/53 ; A61K-031/7068 ; A61K-038/00 ; A61K-009/14 ; A61P-035/00 ; C08G-081/00
国家	印度
专业领域	医药卫生
语种	英语
成果类型	专利
文献类型	科技成果
条目标识符	http://119.78.100.226:8889/handle/3KE4DYBR/21301
专题	中国科学院新疆生态与地理研究所
作者单位	1.INDIA MIN SCI & TECHNOLOGY DEPT BIOTECHN (DBIO-C) 2.BIRLA INST TECHNOLOGY & SCI PILANI (BIRL-Non-standard)
推荐引用方式 GB/T 7714	MITTAL A,JATYAN R,SAHEL D K,et al. Polymeric nano-formulation for delivery of temozolomide, comprises nano-particles, where each particle is composed of component comprising temozolomide hydrazide conjugated to amphiphilic polymer comprising polycarbonate block, polyethylene glycol block and polyester. IN202311047526-A[P]. 2023.

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