Preparing chitosan coated metallic nanoparticles for treating microbial diseases with antibacterial and antifungal activity, comprises preparing chitosan solution and metal precursor solution, adding sodium hydroxide, centrifuging, washing pellet, drying and storing
	MANN N A; SHARMA R; THAKUR N; ALTABBAA S
	2023-07-26
专利权人	UNIV SHOOLINI BIOTECHNOLOGY & MANAGEMENT (USLN-C)
申请日期	2023-07-26
专利号	IN202311050382-A
成果简介	NOVELTY - Preparing chitosan coated metallic nanoparticles comprises preparing chitosan solution by dissolving 700 mg of chitosan in 1% glacial acetic acid (GAA); preparing metal precursor solution by dissolving 0.05 M copper sulfate in 100 mL of distilled water and stirring the mixture at 80 ℃ for 30 minutes; adding 10 mL of chitosan solution dropwise to a precursor solution; heating 15 mL of leaf extract taken from leaves of Lantana camara and Rhamnus triquetra in a water bath at 45 ℃ for 30 minutes; adding leaves extract to the solution and magnetically stirring for 1 hour; adding 1M solution of sodium hydroxide (NaOH) to the solution, stirring for 2 hours, resulting in a color change of the mixture; leaving the suspension undisturbed overnight in a dark environment to obtain precipitates; centrifuging suspension at 4,000 rotations/minute for 40 minutes to obtain pellet, washing with distilled water to remove impurities and drying in oven for 12 hours at 60 ℃; transferring the dried pellet into a clean bottle for further storage. USE - Method of preparing chitosan coated metallic nanoparticles for treating microbial diseases with antibacterial and antifungal activity. The antifungal activity of synthesized nanoparticles and pure extracts against Candida albicans, sample 3 (CuO-CH-Rham-Meth NPs) showed the greatest inhibition zone (23.33 mm) among the nanoparticles, while sample C (Rham-Meth) showed the greatest inhibition zone (19.33 mm) among the pure extracts further depicted in figures 12-14 and table:03. These results suggest that nanoparticles may be more effective than pure extracts at inhibiting the 20 growth of Candida albicans. ADVANTAGE - None given.
IPC 分类号	A01N-059/20 ; A61K-036/72 ; A61P-031/04 ; B82Y-040/00 ; C01G-003/02
国家	印度
专业领域	医药卫生
语种	英语
成果类型	专利
文献类型	科技成果
条目标识符	http://119.78.100.226:8889/handle/3KE4DYBR/21109
专题	中国科学院新疆生态与地理研究所
作者单位	UNIV SHOOLINI BIOTECHNOLOGY & MANAGEMENT (USLN-C)
推荐引用方式 GB/T 7714	MANN N A,SHARMA R,THAKUR N,et al. Preparing chitosan coated metallic nanoparticles for treating microbial diseases with antibacterial and antifungal activity, comprises preparing chitosan solution and metal precursor solution, adding sodium hydroxide, centrifuging, washing pellet, drying and storing. IN202311050382-A[P]. 2023.

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