Preparing 1-((isocyanomethyl)sulfonyl)-4-methylbenzene, involves reacting N-(tosylmethyl) formamide, triethyl amine and phosphorous oxychloride in solvent mixture of dichloromethane and toluene to obtain crude 1- ((isocyanomethyl)sulfonyl)-4-methylbenzene
	SHINGOTE R B; MAHAJAN S S; SAWANT S B; MALI P P
	2023-07-27
专利权人	BLUE JET HEALTHCARE LTD (BLUE-Non-standard)
申请日期	2023-07-27
专利号	IN202321050855-A
成果简介	NOVELTY - Preparing 1-((isocyanomethyl)sulfonyl)-4-methylbenzene, involves (i) reacting sodium metabisulphite in water with toluene sulfonyl chloride in presence of sodium carbonate and sodium bicarbonate at a first predetermined temperature for first predetermined time period to provide sodium 4-methylbenzenesulfinate, (ii) reacting sodium 4-methylbenzenesulfinate with formic acid and formamide in paraformaldehyde at a second predetermined temperature for a second predetermined time period to provide N-(tosylmethyl) formamide, (iii) reacting N-(tosylmethyl) formamide, triethyl amine and phosphorous oxychloride in a solvent mixture of dichloromethane and toluene at a third predetermined temperature for a third predetermined time period to obtain crude 1- ((isocyanomethyl)sulfonyl)-4-methylbenzene and purifying crude 1- ((isocyanomethyl)sulfonyl)-4-methylbenzene by using crystallization in purification solvent, where the purity of 1-((isocyanomethyl)sulfonyl)-4-methylbenzene is 99%. USE - Method for preparing 1-((isocyanomethyl)sulfonyl)-4-methylbenzene. ADVANTAGE - The method enables to prepare 1-((isocyanomethyl)sulfonyl)-4- 5 methylbenzene in a commercial scale with high purity, low technical expenditure and a high yield.
IPC 分类号	C07C-303/02 ; C07C-303/38 ; C07C-309/80 ; C07C-311/16 ; C07D-211/94
国家	印度
专业领域	化学化工
语种	英语
成果类型	专利
文献类型	科技成果
条目标识符	http://119.78.100.226:8889/handle/3KE4DYBR/21083
专题	中国科学院新疆生态与地理研究所
作者单位	BLUE JET HEALTHCARE LTD (BLUE-Non-standard)
推荐引用方式 GB/T 7714	SHINGOTE R B,MAHAJAN S S,SAWANT S B,et al. Preparing 1-((isocyanomethyl)sulfonyl)-4-methylbenzene, involves reacting N-(tosylmethyl) formamide, triethyl amine and phosphorous oxychloride in solvent mixture of dichloromethane and toluene to obtain crude 1- ((isocyanomethyl)sulfonyl)-4-methylbenzene. IN202321050855-A[P]. 2023.

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