Synthesizing ampicillin-loaded polymeric nanoparticle, exhibiting antibacterial activity against Salmonella Typhi, by dissolving ampicillin and PLGA in acetone, adding organic phase to aqueous phase containing PVA, homogenizing mixture, evaporating acetone, centrifuging and rinsing (Hybrid patent)
	KHAN A; KAPOOR D N; SOHAL A; KASHYAP B
	2023-08-07
专利权人	UNIV SHOOLINI BIOTECHNOLOGY & MANAGEMENT (USLN-C)
申请日期	2023-08-07
专利号	IN202311052788-A
成果简介	NOVELTY - Synthesizing an ampicillin-loaded polymeric nanoparticle involves (a) dissolving ampicillin and Poly (lactic-co-glycolic acid) (PLGA) in acetone; (b) adding the organic phase to an aqueous phase containing Polyvinyl alcohol (PVA); (c) homogenizing the mixture; (d) evaporating the acetone; (e) centrifuging the mixture to separate the nanoparticles; and (f) rinsing the nanoparticles with distilled water (Abstract based on the front page). USE - Method for synthesizing an ampicillin-loaded polymeric nanoparticle that exhibiting promising antibacterial activity against Multidrug -resistant (MDR) strains of Salmonella Typhi. No biological data is given. ADVANTAGE - The ampicillin-loaded polymeric nanoparticle has a mean particle size of 991.1 nm and a polydispersity index of 0.441. The zeta potential of the ampicillin-loaded polymeric nanoparticle is -35.2 mV. The entrapment efficiency of the ampicillin-loaded polymeric nanoparticle is 70.70%. The invitro release study shows that the nanoparticles release the drug in a sustained manner, and is more effective than pure ampicillin.
IPC 分类号	A61K-031/74 ; A61K-047/34 ; A61K-009/51 ; B82Y-005/00 ; C01G-049/08
国家	印度
专业领域	医药卫生
语种	英语
成果类型	专利
文献类型	科技成果
条目标识符	http://119.78.100.226:8889/handle/3KE4DYBR/20949
专题	中国科学院新疆生态与地理研究所
作者单位	UNIV SHOOLINI BIOTECHNOLOGY & MANAGEMENT (USLN-C)
推荐引用方式 GB/T 7714	KHAN A,KAPOOR D N,SOHAL A,et al. Synthesizing ampicillin-loaded polymeric nanoparticle, exhibiting antibacterial activity against Salmonella Typhi, by dissolving ampicillin and PLGA in acetone, adding organic phase to aqueous phase containing PVA, homogenizing mixture, evaporating acetone, centrifuging and rinsing (Hybrid patent). IN202311052788-A[P]. 2023.

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