Preparing octreotide or its salt involves forming disulfide bridge by using tert-butyloxycarbonyl (Boc)-D-Phe-Cys(Acm)-Phe-D-Trp(Boc)-Lys(Boc)-Thr(tBu)-Cys(Acm)-Thr(tBu)-O-chlorotrityl chloride (CTC) resin with iodine and de-protecting the protecting groups/cleavage of CTC resin
	THANGARASU P; BALLA K; SIRIKI Y
	2023-08-08
专利权人	ALEMBIC PHARM LTD (ALEM-C)
申请日期	2023-08-08
专利号	IN202321053068-A
成果简介	NOVELTY - Preparing octreotide or its salt involves forming disulfide bridge by using tert-butyloxycarbonyl (Boc)-D-Phe-Cys(Acm)-Phe-D-Trp(Boc)-Lys(Boc)-Thr(tBu)-Cys(Acm)-Thr(tBu)-O-chlorotrityl chloride (CTC) resin with iodine to obtain a sequence of 13 amino acid sequence SEQ ID NO: 1A as shown in formula (I) followed by de-protecting the protecting groups/cleavage of CTC resin of SEQ ID NO: 1A. USE - Method for preparing octreotide or its salt. ADVANTAGE - The octreotide is prepared using coupling additive, which reduces loss of configuration at the carboxylic acid residue, increases coupling rates and reduces the risk of racemization.
IPC 分类号	C07K-001/04 ; C07K-001/06 ; C07K-001/20 ; C07K-007/06
国家	印度
专业领域	医药卫生
语种	英语
成果类型	专利
文献类型	科技成果
条目标识符	http://119.78.100.226:8889/handle/3KE4DYBR/20910
专题	中国科学院新疆生态与地理研究所
作者单位	ALEMBIC PHARM LTD (ALEM-C)
推荐引用方式 GB/T 7714	THANGARASU P,BALLA K,SIRIKI Y. Preparing octreotide or its salt involves forming disulfide bridge by using tert-butyloxycarbonyl (Boc)-D-Phe-Cys(Acm)-Phe-D-Trp(Boc)-Lys(Boc)-Thr(tBu)-Cys(Acm)-Thr(tBu)-O-chlorotrityl chloride (CTC) resin with iodine and de-protecting the protecting groups/cleavage of CTC resin. IN202321053068-A[P]. 2023.

条目包含的文件
条目无相关文件。

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。