Controlled release pharmaceutical composition of mirabegron used for e.g. symptomatic treatment of urgency, increased micturition frequency and urgency incontinence, comprises mirabegron and non hydrogel-forming excipient selected from e.g. glyceryl dibehenate, ethyl cellulose and cellulose acetate
	KARDILE C A; MANJAREKAR R G; SAGARE A R; SHAH D B; SHAH P B
	2023-08-10
专利权人	TITAN LAB PVT LTD (TITA-Non-standard)
申请日期	2023-08-10
专利号	IN202321053833-A
成果简介	NOVELTY - Controlled release pharmaceutical composition of mirabegron comprises mirabegron or its salt and a non hydrogel- forming excipient selected from glyceryl dibehenate, ethyl cellulose, cellulose acetate, amino methacrylate copolymer or methacrylate copolymer and at least one pharmaceutical excipient; or, comprises a core comprising mirabegron or its salt and a non hydrogel- forming excipient selected from glycerol dibehenate, ethyl cellulose, cellulose acetate or its mixtures, and a coating layer comprising a polymer selected from ethyl cellulose, cellulose acetate, amino methacrylate copolymer, methacrylate copolymer or its mixtures. USE - Controlled release pharmaceutical composition of mirabegron used for symptomatic treatment of urgency, increased micturition frequency and/or urgency incontinence as may occur in patients with overactive bladder syndrome. No biological data is given. ADVANTAGE - The controlled release composition of mirabegron is simple, and easy to manufacture. The composition exhibited dissolution profile of > 20% in 1 hour, 30-75% in 5 hours and ≮ 80% in 10 hours when tested in a USP type 1 (Basket) apparatus at 100 Revolutions per minute (rpms) in 900 ml of an acetate buffer of 3.5 pH at a temperature of 37 ± 0.5 ℃.
IPC 分类号	A61K-031/426 ; A61K-047/14 ; A61K-047/30 ; A61K-009/16 ; A61K-009/20
国家	印度
专业领域	医药卫生
语种	英语
成果类型	专利
文献类型	科技成果
条目标识符	http://119.78.100.226:8889/handle/3KE4DYBR/20887
专题	中国科学院新疆生态与地理研究所
作者单位	TITAN LAB PVT LTD (TITA-Non-standard)
推荐引用方式 GB/T 7714	KARDILE C A,MANJAREKAR R G,SAGARE A R,et al. Controlled release pharmaceutical composition of mirabegron used for e.g. symptomatic treatment of urgency, increased micturition frequency and urgency incontinence, comprises mirabegron and non hydrogel-forming excipient selected from e.g. glyceryl dibehenate, ethyl cellulose and cellulose acetate. IN202321053833-A[P]. 2023.

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