| SELENIUM NANOPARTICLE COATED WITH MULTI-KINASE INHIBITOR SORAFENIB, WITH ANTIFIBROTIC ACTION AND METHOD FOR PRODUCTION THEREOF | |
| 2023-08-10 | |
| 专利权人 | TUROVSKY E A (TURO-Individual) ; VARLAMOVA E G (VARL-Individual) ; SIMAKIN A V (SIMA-Individual) ; GUDKOV S V (GUDK-Individual) |
| 申请日期 | 2023-08-10 |
| 专利号 | RU2825399-C1 |
| 成果简介 | NOVELTY - Invention relates to therapeutic use of selenium nanoparticles coated with sorafenib. Disclosed is the use of selenium nanoparticles coated with the multikinase inhibitor sorafenib for the treatment of hepatic fibrosis, where selenium nanoparticles are obtained by laser ablation and have size of 100–120 nm, wherein the thickness of the sorafenib layer is 10–20 nm. USE - Medicine. ADVANTAGE - Said use reduces the level of expression of fibrosis marker genes and the number of collagen fibers, as well as reduces the length of collagen fibers in liver tissue; integrated studies have shown high efficacy of therapeutic application of selenium nanoparticles coated with sorafenib for treating severe hepatic fibrosis and potential regression of micronodular cirrhosis. 1 cl, 12 dwg, 1 ex |
| IPC 分类号 | A61K-031/44 ; A61K-033/04 ; A61P-035/00 ; B01J-019/08 ; B82Y-005/00 |
| 国家 | 俄罗斯 |
| 专业领域 | 生物科学 |
| 语种 | 英语 |
| 成果类型 | 专利 |
| 文献类型 | 科技成果 |
| 条目标识符 | http://119.78.100.226:8889/handle/3KE4DYBR/20878 |
| 专题 | 中国科学院新疆生态与地理研究所 |
| 作者单位 | 1.TUROVSKY E A (TURO-Individual) 2.VARLAMOVA E G (VARL-Individual) 3.SIMAKIN A V (SIMA-Individual) 4.GUDKOV S V (GUDK-Individual) |
| 推荐引用方式 GB/T 7714 | TUROVSKY E A,VARLAMOVA E G,SIMAKIN A V,et al. SELENIUM NANOPARTICLE COATED WITH MULTI-KINASE INHIBITOR SORAFENIB, WITH ANTIFIBROTIC ACTION AND METHOD FOR PRODUCTION THEREOF. RU2825399-C1[P]. 2023. |
| 条目包含的文件 | 条目无相关文件。 | |||||
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