Preparing tetraazacyclododecane-tetraacetic acid for applying in formulation of active pharmaceutical ingredients especially magnetic resonance imaging contrast agents, comprises treating tetraazacyclododecane-tetraacetic acid with inorganic acid, crystallizing, and precipitating
	NAMBIAR S; SIVADAS A; NARAYANAN D; VILVAN M; GANESAN V
	2023-08-11
专利权人	SOLARA ACTIVE PHARMA SCI LTD (SOLA-Non-standard)
申请日期	2023-08-11
专利号	IN202341054046-A
成果简介	NOVELTY - Preparing DOTA (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid) comprises (i) treating an aqueous solution of DOTA having 0.00-0.75 pH with an inorganic acid; (ii) crystallizing the salt of DOTA as a solid from the aqueous solution; (iii) recrystallizing the crystallized salt of DOTA in a mixture of organic solvent and water at a pH less than 0.75; (iv) preparing aqueous solution of the recrystallized salt of DOTA at 3.0-5.0 pH; (v) treating the prepared aqueous solution of salt of DOTA with anionic resin at 3.0-5.0 pH to obtain an aqueous solution of DOTA; and (vi) adding an organic solvent to the filtered aqueous solution of DOTA; and (vii) precipitating DOTA from the solution in solid form. USE - Method for preparing DOTA (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid) for applying in formulation of active pharmaceutical ingredients especially magnetic resonance imaging contrast agents. ADVANTAGE - None given.
IPC 分类号	A61K-047/58 ; A61K-049/10 ; C07C-227/42 ; C07C-229/26 ; C07D-257/02
国家	印度
专业领域	医药卫生
语种	英语
成果类型	专利
文献类型	科技成果
条目标识符	http://119.78.100.226:8889/handle/3KE4DYBR/20859
专题	中国科学院新疆生态与地理研究所
作者单位	SOLARA ACTIVE PHARMA SCI LTD (SOLA-Non-standard)
推荐引用方式 GB/T 7714	NAMBIAR S,SIVADAS A,NARAYANAN D,et al. Preparing tetraazacyclododecane-tetraacetic acid for applying in formulation of active pharmaceutical ingredients especially magnetic resonance imaging contrast agents, comprises treating tetraazacyclododecane-tetraacetic acid with inorganic acid, crystallizing, and precipitating. IN202341054046-A[P]. 2023.

条目包含的文件
条目无相关文件。

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。