Bioactive mesoporous silica nanoparticle based active and its formulations as gel for combating ROS levels and neuron regeneration in traumatic brain injury, comprises amine functionalized mesoporous silica nanoparticles as carrier for therapeutic payloads coated with polydopamine
	ROY R; ARSHI M U; GUPTA S; JANA A; GARG S; GHOSH S
	2023-08-12
专利权人	INDIAN INST TECHNOLOGY JODHPUR (INTE-Non-standard)
申请日期	2023-08-12
专利号	IN202311054293-A
成果简介	NOVELTY - Bioactive mesoporous silica nanoparticle based active, and its formulations comprises a co-acting large pore-size of ~4.5 nm amine functionalized Mesoporous silica nanoparticles (L-MSN) as carrier for therapeutic payloads coated with Polydopamine (PDA) for delivery of therapeutic payloads and scavenging of Reactive oxygen species (ROS) for favorable neurogenesis. USE - Bioactive mesoporous silica nanoparticle based active and its formulations as carrier or gel for combating ROS levels and neuron regeneration in traumatic brain injury. Test details are described, but no results are given. ADVANTAGE - The PDA-AMSN-D in the formulation having excellent biocompatibility with neuroblastoma cell line (SH-SY5Y) and elegant cell lines such as mesenchymal stem cells (hMSCs) enables reduced neuroinflammation, bestow blood-brain barrier (BBB) protection, confer neuroprotective effect, and promote neuron regeneration and functional recovery, with the amalgamation of Gel/ PDA-AMSN-D being adapted as AND logic gate, where both NCM in PDA-AMSNs mitigate injury outcomes and contribute to the neurological functional recovery. DETAILED DESCRIPTION - An INDEPENDENT CLAIM is included for a method of manufacturing of bioactive mesoporous silica nanoparticle based active and its formulations which involves: (a) providing large pore based mesoporous silica nanoparticles MSN; (b) modifying the mesoporous silica nanoparticles with amine to obtain amine functionalized AMSN that is optionally loaded with Neuroregenerative chemical modulator (NCM)/drugs as AMSN-D; and (c) coating with dopamine by oxidative self polymerization in weakly alkaline conditions to achieve the bioactive mesoporous silica nanoparticle based active preferably as Polydopamine (PDA) coated Amine-functionalized bioactive mesoporous silica nanoparticles (AMSN) of (PDA-AMSN) and/or (PDA-AMSN-D).
IPC 分类号	A61K-031/121 ; A61K-031/704 ; A61K-047/34 ; A61K-047/54 ; A61K-047/62 ; A61K-047/69 ; A61K-009/51
国家	印度
专业领域	医药卫生
语种	英语
成果类型	专利
文献类型	科技成果
条目标识符	http://119.78.100.226:8889/handle/3KE4DYBR/20829
专题	中国科学院新疆生态与地理研究所
作者单位	INDIAN INST TECHNOLOGY JODHPUR (INTE-Non-standard)
推荐引用方式 GB/T 7714	ROY R,ARSHI M U,GUPTA S,et al. Bioactive mesoporous silica nanoparticle based active and its formulations as gel for combating ROS levels and neuron regeneration in traumatic brain injury, comprises amine functionalized mesoporous silica nanoparticles as carrier for therapeutic payloads coated with polydopamine. IN202311054293-A[P]. 2023.

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