Preparing glucagon or a pharmaceutically acceptable salt involves loading fluorenylmethoxycarbonyl protected threonine with side chain protection to resin solid-phase support in the presence of coupling agent, and deprotecting fluorenylmethoxycarbonyl group using deprotecting agent
	GIRASE P; KODIDASU A; YOGESHA; KAMBLE M; PONNUSAMY T; RAMU V G
	2023-08-24
专利权人	ALEMBIC PHARM LTD (ALEM-C)
申请日期	2023-08-24
专利号	IN202321056791-A
成果简介	NOVELTY - Preparing glucagon or a pharmaceutically acceptable salt involves using a compound selected from compounds having 4 amino acid sequence (SEQ ID NO: 1), 5 amino acid sequence (SEQ ID NO: 2), 3 amino acid sequence (SEQ ID NO: 3), 5 amino acid sequence (SEQ ID NO: 4), and 3 amino acid sequence (SEQ ID NO: 5), given in the specification or a pharmaceutically acceptable salt. USE - Method for preparing glucagon or a pharmaceutically acceptable salt. ADVANTAGE - The method allows to obtain essentially pure glucagon or a pharmaceutically acceptable salt containing not more than 0.5% of any individual impurity or peptidic impurity, preferably not more than 0.2% DETAILED DESCRIPTION - Preparing glucagon or a pharmaceutically acceptable salt involves using a compound selected from compounds having 4 amino acid sequence Fmoc-Phe-Thr-Ser-Asp-OH (SEQ ID NO: 1), 5 amino acid sequence His-Ser-Gln-Gly-Thr (SEQ ID NO: 2), 3 amino acid sequence Boc-His-Ser-Gln-OH (SEQ ID NO: 3), 5 amino acid sequence Fmoc-Gly-Thr-Phe-Thr-Ser-OH (SEQ ID NO: 4), and 3 amino acid sequence Fmoc-Phe-Thr-Ser-OH (SEQ ID NO: 5) or a pharmaceutically acceptable salt.
IPC 分类号	A61K-038/26 ; A61P-003/10 ; C07C-045/68 ; C07F-009/12 ; C07K-014/605
国家	印度
专业领域	医药卫生
语种	英语
成果类型	专利
文献类型	科技成果
条目标识符	http://119.78.100.226:8889/handle/3KE4DYBR/20708
专题	中国科学院新疆生态与地理研究所
作者单位	ALEMBIC PHARM LTD (ALEM-C)
推荐引用方式 GB/T 7714	GIRASE P,KODIDASU A,YOGESHA,et al. Preparing glucagon or a pharmaceutically acceptable salt involves loading fluorenylmethoxycarbonyl protected threonine with side chain protection to resin solid-phase support in the presence of coupling agent, and deprotecting fluorenylmethoxycarbonyl group using deprotecting agent. IN202321056791-A[P]. 2023.

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