| Preparing ketoprostanozol and its intermediates, used as a reference material for detecting prostanozol intake, involves coupling stanolone with ethyl formate, coupling androstan-17b-ol-3-one derivative with hydrazine reagent in acid, oxidizing stanozolol derivative with dess Martin Periodinane | |
| 2023-09-01 | |
| 专利权人 | NAT DOPE TESTING LAB (NADO-Non-standard) ; COUNCIL SCI & IND RES SOUTH AFRICA (COUL-C) |
| 申请日期 | 2023-09-01 |
| 专利号 | IN202311059079-A |
| 成果简介 | NOVELTY - Preparing 17-ketoprostanozol (I) and its intermediates, involves (a) coupling of stanolone (II) with ethyl formate to obtain androstan-17b-ol-3-one derivative (III); (b) coupling of the androstan-17b-ol-3-one derivative (III) obtained with a hydrazine reagent in presence of an acid and solvent to provide pyrazol-17-ol Nor stanozolol derivative (IV); (c) oxidizing 17-ol Nor stanozolol derivative (IV) obtained with Dess Martin Periodinane (DMP) in presence of a solvent to obtain 17- ketoprostanozol (I). USE - Process for preparing 17-ketoprostanozol (I) and its intermediates, used as an authentic reference material for detecting prostanozol intake through the analysis of biological samples obtained from athletes. ADVANTAGE - The (I) has high purity of 99.6%, and high yield of 90 %. The process is fast, completes within 15-30 minutes, more reliable and robust, and does not have any formation of side products. DETAILED DESCRIPTION - Preparing 17-ketoprostanozol of formula (I) and its intermediates, involves (a) coupling of stanolone of formula (II) with ethyl formate to obtain androstan-17b-ol-3-one derivative of formula (III); (b) coupling of the androstan-17b-ol-3-one derivative (III) obtained with a hydrazine reagent in presence of an acid and solvent to provide pyrazol-17-ol Nor stanozolol derivative of formula (IV); (c) oxidizing 17-ol Nor stanozolol derivative (IV) obtained with Dess Martin Periodinane (DMP) in presence of a solvent to obtain 17- ketoprostanozol (I). |
| IPC 分类号 | C07J-001/00 ; C07J-021/00 ; C07J-003/00 ; G01N-030/72 |
| 国家 | 印度 |
| 专业领域 | 医药卫生 |
| 语种 | 英语 |
| 成果类型 | 专利 |
| 文献类型 | 科技成果 |
| 条目标识符 | http://119.78.100.226:8889/handle/3KE4DYBR/20570 |
| 专题 | 中国科学院新疆生态与地理研究所 |
| 作者单位 | 1.NAT DOPE TESTING LAB (NADO-Non-standard) 2.COUNCIL SCI & IND RES SOUTH AFRICA (COUL-C) |
| 推荐引用方式 GB/T 7714 | AHMED Z,SAHU P L,SONI A,et al. Preparing ketoprostanozol and its intermediates, used as a reference material for detecting prostanozol intake, involves coupling stanolone with ethyl formate, coupling androstan-17b-ol-3-one derivative with hydrazine reagent in acid, oxidizing stanozolol derivative with dess Martin Periodinane. IN202311059079-A[P]. 2023. |
| 条目包含的文件 | 条目无相关文件。 | |||||
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