Organic-oil integrated poly (DL-lactide-co-glycolide) nanoparticle for providing antioxidant, antiinflammatory and anti-cancer effects; used for cancer therapy for treating breast cancer; used in drug delivery and biomedical research, comprises Syzygium aromaticum, folic acid and eugenol
	KHAN A; KAPOOR D N; KASHYAP B
	2023-09-04
专利权人	UNIV SHOOLINI BIOTECHNOLOGY & MANAGEMENT (USLN-C)
申请日期	2023-09-04
专利号	IN202311059089-A
成果简介	NOVELTY - Organic-oil integrated poly (DL-lactide-co-glycolide) (PLGA) nanoparticle, comprises Syzygium aromaticum; folic acid; and eugenol; where the nanoparticle is integrated with folic acid and loaded with eugenol in a ratio selected from 1:1, 1:2 and 1:3; the eugenol is extracted from the herbal plant Syzygium aromaticum; the nanoparticle exhibit a cytotoxic effect of up to 21.70%. USE - Organic-oil integrated poly (DL-lactide-co-glycolide) (PLGA) nanoparticle for providing antioxidant, antiinflammatory and anti-cancer effects (claimed); used for cancer therapy for treating breast cancer; used in drug delivery and biomedical research. The ability of nanoparticles for anti-inflammatory activity was tested by bovine serum albumin (BSA) assay using in-vitro method. The result showed that the nanoparticles has IC50value of 23.74 µg/ml. ADVANTAGE - The nanoparticle exhibits a high drug entrapment efficiency of 87.51%, zeta potential of -32.0 mV and an antioxidant potential of 85.28%. DETAILED DESCRIPTION - An INDEPENDENT CLAIM is included for a process for preparation of the PLGA nanoparticle, comprising; (a) dissolving PLGA in 10 ml dichloromethane (DCM) to form a solution; (b) solubilizing 1wt.vol.% polyvinyl alcohol (PVA) in 40 ml distilled water along with 40 ml DCM to form a solution; (c) mixing both solutions to form oil-in-water emulsion; (d) cooling and sonicating the emulsion for 20 minutes; (e) diluting the oil-in-water emulsion with distilled water using magnetic stirring; (f) centrifuging at 12,000 revolutions per minute (rpm) rpm for 30 minutes and collecting the pellet; and (g) freezing and storing the nanoparticle at 4 °C in an airtight bottle.
IPC 分类号	A61K-045/06 ; A61K-047/69 ; A61K-009/51 ; A61L-027/54 ; A61P-035/00
国家	印度
专业领域	医药卫生
语种	英语
成果类型	专利
文献类型	科技成果
条目标识符	http://119.78.100.226:8889/handle/3KE4DYBR/20531
专题	中国科学院新疆生态与地理研究所
作者单位	UNIV SHOOLINI BIOTECHNOLOGY & MANAGEMENT (USLN-C)
推荐引用方式 GB/T 7714	KHAN A,KAPOOR D N,KASHYAP B. Organic-oil integrated poly (DL-lactide-co-glycolide) nanoparticle for providing antioxidant, antiinflammatory and anti-cancer effects; used for cancer therapy for treating breast cancer; used in drug delivery and biomedical research, comprises Syzygium aromaticum, folic acid and eugenol. IN202311059089-A[P]. 2023.

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