Synthesizing bisphosphonate for treating Paget's disease involves mixing adipic acid ester derivative, phosphorous acid, and halo phosphorous compound; heating reaction mixture; cooling, adding water and base solution to it followed by addition of solvent stirring, washing precipitate with ethanol
	SREEDHARAN P; GEORGE L H; SIVAKAMIAMMAL S G
	2023-09-05
专利权人	UNIV COCHIN SCI & TECHNOLOGY (UYCO-Non-standard)
申请日期	2023-09-05
专利号	IN202341059731-A
成果简介	NOVELTY - Synthesizing biocompatible bisphosphonate (I), involves (a) mixing adipic acid ester derivative, phosphorous acid, and a halo phosphorous compound under stirring at 200-400 rpm to obtain a reaction mixture; (b) heating the reaction mixture within an hour at 60-100 °C under nitrogen atmosphere and refluxing for 14-16 hours followed by addition of cold water to quench the reaction mixture; (c) heating the quenched reaction mixture at 90- 100 °C until the volume of reaction mixture has reduced to 5-15 %; (d) cooling the reduced volume of quenched reaction mixture and adding water and base solution to it to maintain pH of 3 followed by addition of solvent to obtain a reaction mixture; and (e) stirring the reaction mixture at 25-30 °C at 200-400 rpm for 14-16 hours to obtain precipitate of bisphosphonate (I); and (f) washing the precipitate with the ethanol to obtain bisphosphonate (I). USE - Process for synthesizing biocompatible bisphosphonate (I) used for treating post-menopausal osteoporosis, glucocorticoid induced osteoporosis, Paget's disease of bone, metastatic bone diseases, hypercalcemia of malignancy. No biological data given. ADVANTAGE - The process is biocompatible, cost-effective, rapid and efficient. The (I) has high purity. DETAILED DESCRIPTION - Synthesizing biocompatible bisphosphonate of formula (I), involves (a) mixing adipic acid ester derivative, phosphorous acid, and a halo phosphorous compound under stirring at 200-400 rpm to obtain a reaction mixture; (b) heating the reaction mixture within an hour at 60-100 °C under N2 atmosphere and refluxing for 14-16 hours followed by addition of cold water to quench the reaction mixture; (c) heating the quenched reaction mixture at 90- 100 °C until the volume of reaction mixture has reduced to 5-15 %; (d) cooling the reduced volume of quenched reaction mixture and adding water and base solution to it to maintain pH of 3 followed by addition of solvent to obtain a reaction mixture; and (e) stirring the reaction mixture at 25-30 °C at 200-400 rpm for 14-16 hours to obtain precipitate of bisphosphonate (I); and (f) washing the precipitate with the ethanol to obtain bisphosphonate (I).
IPC 分类号	C07D-213/04 ; C07F-009/28 ; C07F-009/58 ; C07F-009/6506
国家	印度
专业领域	医药卫生
语种	英语
成果类型	专利
文献类型	科技成果
条目标识符	http://119.78.100.226:8889/handle/3KE4DYBR/20494
专题	中国科学院新疆生态与地理研究所
作者单位	UNIV COCHIN SCI & TECHNOLOGY (UYCO-Non-standard)
推荐引用方式 GB/T 7714	SREEDHARAN P,GEORGE L H,SIVAKAMIAMMAL S G. Synthesizing bisphosphonate for treating Paget's disease involves mixing adipic acid ester derivative, phosphorous acid, and halo phosphorous compound; heating reaction mixture; cooling, adding water and base solution to it followed by addition of solvent stirring, washing precipitate with ethanol. IN202341059731-A[P]. 2023.

条目包含的文件
条目无相关文件。

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。