Preparing solid dispersion of mavacamten, used for potential oral treatment of genetic cardiomyopathies e.g. obstructive hypertrophic cardiomyopathy, by providing acid addition salt of mavacamten and solvent, neutralizing with base, adding excipient, removing solvent and isolating solid dispersion
	BABU U P; MUCHERLA N P; VEERNALA R K; MADHRA M K; GADDAMEEDHI P R; VALLAMREDDY H K R
	2023-09-07
专利权人	DR REDDY'S LAB LTD (REDY-C)
申请日期	2023-09-07
专利号	IN202341060203-A
成果简介	NOVELTY - Preparing solid dispersion of mavacamten involves (a) providing an acid addition salt of mavacamten and a solvent, (b) neutralizing the acid addition salt of mavacamten with a base, (c) adding a pharmaceutical excipient to the solution obtained in step (b), (d) removing the solvent from the solution obtained in step (c), and (e) isolating solid dispersion of mavacamten. USE - Method for preparing solid dispersion of mavacamten, that used for the potential oral treatment of genetic cardiomyopathies comprising obstructive Hypertrophic cardiomyopathy (HCM) and obstructive HCM. No biological data is given. ADVANTAGE - The method provides stable and pure solid-state forms of mavacamten with control hygroscopicity and improved stability. DETAILED DESCRIPTION - An INDEPENDENT CLAIM is included for a method for preparation of an acid addition salt of mavacamten which involves: (a) providing a mixture of mavacamten and a solvent; (b) adding an acid into the mixture; and (c) isolating acid addition salt of mavacamten.
IPC 分类号	A61K-031/513 ; A61K-047/32 ; A61K-047/38 ; C07D-239/10
国家	印度
专业领域	医药卫生
语种	英语
成果类型	专利
文献类型	科技成果
条目标识符	http://119.78.100.226:8889/handle/3KE4DYBR/20472
专题	中国科学院新疆生态与地理研究所
作者单位	DR REDDY'S LAB LTD (REDY-C)
推荐引用方式 GB/T 7714	BABU U P,MUCHERLA N P,VEERNALA R K,et al. Preparing solid dispersion of mavacamten, used for potential oral treatment of genetic cardiomyopathies e.g. obstructive hypertrophic cardiomyopathy, by providing acid addition salt of mavacamten and solvent, neutralizing with base, adding excipient, removing solvent and isolating solid dispersion. IN202341060203-A[P]. 2023.

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