Preparing bempedoic acid comprises hydrolyzing diethyltetramethyloxopentadecanedioate with esterase in presence of suitable base to obtain tetramethyloxopentadecanedioic acid and reducing in presence of keto reductase to obtain product
	DILPREET S; ASHISH T K; MANI B K; KANT T S; ASHOK P
	2023-09-11
专利权人	IND-SWIFT LAB LTD (INSW-Non-standard)
申请日期	2023-09-11
专利号	IN202311061068-A
成果简介	NOVELTY - Preparing bempedoic acid of formula (I) comprises hydrolyzing diethyl 2,2',14,14'-tetramethyl-8-oxopentadecanedioate of formula (II) with an esterase in presence of suitable base to obtain 2,2',14,14'-tetramethyl-8-oxopentadecanedioic acid of formula (III), and reducing in the presence of keto reductase to obtain the product. USE - Method for preparing bempedoic acid. ADVANTAGE - The method is eco-friendly and efficient, provides bempedoic acid compound having high purity and yield, and uses enzymatic or chemo-enzymatic reactions which effectively reduces the overall cost for synthesis of the bempedoic acid. DETAILED DESCRIPTION - Preparing bempedoic acid of formula (I) comprises hydrolyzing diethyl 2,2',14,14'-tetramethyl-8-oxopentadecanedioate of formula (II) with an esterase in presence of suitable base to obtain 2, 2',14,14'-tetramethyl-8-oxopentadecanedioic acid of formula (III), and reducing in the presence of keto reductase to obtain the product, where R is carboxylic acid protecting group.
IPC 分类号	C07B-041/08 ; C07C-051/09 ; C07C-051/353 ; C07C-059/01 ; C07D-477/20
国家	印度
专业领域	医药卫生
语种	英语
成果类型	专利
文献类型	科技成果
条目标识符	http://119.78.100.226:8889/handle/3KE4DYBR/20443
专题	中国科学院新疆生态与地理研究所
作者单位	IND-SWIFT LAB LTD (INSW-Non-standard)
推荐引用方式 GB/T 7714	DILPREET S,ASHISH T K,MANI B K,et al. Preparing bempedoic acid comprises hydrolyzing diethyltetramethyloxopentadecanedioate with esterase in presence of suitable base to obtain tetramethyloxopentadecanedioic acid and reducing in presence of keto reductase to obtain product. IN202311061068-A[P]. 2023.

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