Use of heat-killed single serotype Shigella immunogen for strong protection against wild-type shigellae after oral immunization with heat killed multi-serotype shigella immunogen
	MIYOSHI S; OKAMOTO K; DUTTA S; MUKHOPADHYAY A K; MAITI S; KOLEY H
	2023-09-12
专利权人	UNIV OKAYAMA (UYOK-C) ; INDIAN COUNCIL MEDICAL RES (INCO-Non-standard)
申请日期	2023-09-12
专利号	IN202311061296-A
成果简介	NOVELTY - Use of heat-killed single serotype Shigella immunogen is claimed for strong protection against wild-type shigellae after oral immunization with heat killed multi-serotype shigella (HKMS) immunogen. USE - Heat-killed single serotype Shigella immunogen used for strong protection against wild-type shigellae after oral immunization with heat killed multi-serotype shigella (HKMS) immunogen. No biological data given. ADVANTAGE - The heat-killed single serotype Shigella immunogen is safe, effective and cost-effective, and it demonstrates only homologous protection in mice model without any heterologous protection or cross protection. DETAILED DESCRIPTION - An INDEPENDENT CLAIM is included for method for formulating heat killed Shigella immunogen, which involves: (1) growing strains in different agar and broth medium at 37℃ with constant shaking. (2) maximizing the antigen presence in formulated immunogen cultures from all the agar medium and broth medium was collected on next day and suspended in phosphate buffer saline (PBS) separately. (3) collecting bacteria from agar media, them scrapping plates and washing twice with PBS and re-suspending bacteria in PBS; (4) centrifuging broth mediums and discarding the culture supernatant; and (5) washing the bacterial pellets twice with PBS and resuspending in PBS.
IPC 分类号	A61K-039/00 ; A61K-039/112 ; A61K-039/12 ; A61P-031/04 ; C07K-014/25
国家	印度
专业领域	医药卫生
语种	英语
成果类型	专利
文献类型	科技成果
条目标识符	http://119.78.100.226:8889/handle/3KE4DYBR/20424
专题	中国科学院新疆生态与地理研究所
作者单位	1.UNIV OKAYAMA (UYOK-C) 2.INDIAN COUNCIL MEDICAL RES (INCO-Non-standard)
推荐引用方式 GB/T 7714	MIYOSHI S,OKAMOTO K,DUTTA S,et al. Use of heat-killed single serotype Shigella immunogen for strong protection against wild-type shigellae after oral immunization with heat killed multi-serotype shigella immunogen. IN202311061296-A[P]. 2023.

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