Preparing crystalline form of cortexolone alpha-propionate comprises providing a solution of cortexolone alpha-propionate in ethanol, combining with n-hexane to obtain mixture, stirring, and isolating crystalline form III of cortexolone alpha-propionate
	RAMBABU K V; KUNDETI P; RAVURI S; KOLLA R
	2023-09-12
专利权人	PULSE PHARM PVT LTD (PULS-Non-standard)
申请日期	2023-09-12
专利号	IN202341061335-A
成果简介	NOVELTY - Preparing crystalline form III of cortexolone 17 alpha-propionate (I) comprises (a) providing a solution of cortexolone 17 alpha-propionate in ethanol; (b) combining solution of cortexolone 17 alpha-propionate with n-hexane to obtain a mixture; (c) maintaining the mixture at 0-5 ℃ (± 2 ℃), and stirring the mixture for 25-35 minutes; and (d) isolating crystalline form III of cortexolone 17 alpha-propionate. USE - Method for preparing crystalline form III of cortexolone 17 alpha-propionate. ADVANTAGE - The method provides good quality of cortexolone 17 alpha propionate with desired polymorphic form III and chromatographic purity of 99.9% with minimal use of organic solvents in a simple single-pot process. DETAILED DESCRIPTION - Preparing crystalline form III of cortexolone 17 alpha-propionate of formula (I) comprises (a) providing a solution of cortexolone 17 alpha-propionate in ethanol; (b) combining solution of cortexolone 17 alpha-propionate with n-hexane to obtain a mixture; (c) maintaining the mixture at 0-5 ℃ (± 2 ℃), and stirring the mixture for 25-35 minutes; and (d) isolating crystalline form III of cortexolone 17 alpha-propionate.
IPC 分类号	A61K-031/573 ; A61P-005/28 ; C07J-005/00 ; C12P-033/00
国家	印度
专业领域	医药卫生
语种	英语
成果类型	专利
文献类型	科技成果
条目标识符	http://119.78.100.226:8889/handle/3KE4DYBR/20421
专题	中国科学院新疆生态与地理研究所
作者单位	PULSE PHARM PVT LTD (PULS-Non-standard)
推荐引用方式 GB/T 7714	RAMBABU K V,KUNDETI P,RAVURI S,et al. Preparing crystalline form of cortexolone alpha-propionate comprises providing a solution of cortexolone alpha-propionate in ethanol, combining with n-hexane to obtain mixture, stirring, and isolating crystalline form III of cortexolone alpha-propionate. IN202341061335-A[P]. 2023.

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