Preparing methadone hydrochloride comprises condensing diphenyl acetonitrile with l-dimethylamino-2- chloropropane, subjecting methadone nitrile to solvent extraction, extracting methadone nitrile acid addition salt solution, subjecting in halogenated hydrocarbon to evaporation
	BABAN C S; SURESH H S; KISHORE D V P; LILADHAR B N; ANILRAO K S
	2023-09-13
专利权人	EMBIO LTD (EMBI-Non-standard)
申请日期	2023-09-13
专利号	IN202321061598-A
成果简介	NOVELTY - Preparing methadone hydrochloride comprises: (a) condensing diphenyl acetonitrile with l-dimethylamino-2- chloropropane in the presence of base and water in the solvent to obtain methadone nitrile; (b) subjecting the obtained methadone nitrile to solvent extraction; (c) subjecting the extracted methadone nitrile to acid treatment to obtain methadone nitrile acid addition salt; (d) extracting the obtained methadone nitrile acid addition salt solution in a halogenated solvent; (e) subjecting the methadone nitrile acid addition salt in halogenated hydrocarbon to evaporation to obtain methadone nitrile acid addition salt; (f) subjecting the obtained crude methadone nitrile acid addition salt to purification; (g) adding methadone nitrile acid addition salt to ethyl magnesium bromide to obtain isolated methadone; and (h) isolating methadone hydrochloride by treatment of hydrochloric acid to methadone. USE - Method for preparing methadone hydrochloride. ADVANTAGE - The method provides methadone hydrochloride with a purity of 99% and the percentage impurity of isomethadone hydrochloride less than 0.1%, and is from regioisomer isomethadone hydrochloride impurity.
IPC 分类号	A61K-031/137 ; A61K-047/38 ; A61K-009/20 ; A61P-025/30 ; A61P-025/36
国家	印度
专业领域	医药卫生
语种	英语
成果类型	专利
文献类型	科技成果
条目标识符	http://119.78.100.226:8889/handle/3KE4DYBR/20418
专题	中国科学院新疆生态与地理研究所
作者单位	EMBIO LTD (EMBI-Non-standard)
推荐引用方式 GB/T 7714	BABAN C S,SURESH H S,KISHORE D V P,et al. Preparing methadone hydrochloride comprises condensing diphenyl acetonitrile with l-dimethylamino-2- chloropropane, subjecting methadone nitrile to solvent extraction, extracting methadone nitrile acid addition salt solution, subjecting in halogenated hydrocarbon to evaporation. IN202321061598-A[P]. 2023.

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