Preparing abrocitinib for treating atopic dermatitis (eczema), comprises treating methylamino cyclobutane compound or its salt with 4-halo-7H-pyrrolo[2,3-d]pyrimidine compound
	KUMAR N; CHATURVEDI V; BHAVSAR J; KUMAR A; KUKREJA H
	2023-09-19
专利权人	MANKIND PHARMA LTD (MANK-Non-standard)
申请日期	2023-09-19
专利号	IN202311062811-A
成果简介	NOVELTY - Preparing abrocitinib (I) or its salt comprises treating methylamino cyclobutane compound (II) or its salt with 4-halo-7H-pyrrolo[2,3-d]pyrimidine compound (III). USE - Method for preparing abrocitinib for treating atopic dermatitis (eczema). No biological data given. ADVANTAGE - The method provides abrocitinib (I) with high purity of 99%, optical purity of 99.5%, and high yield, and the method is reproducible and easy to handle during large scale production. DETAILED DESCRIPTION - Preparing abrocitinib of formula (I) or its salt comprises treating methylamino cyclobutane compound of formula (II) or its salt with 4-halo-7H-pyrrolo[2,3-d]pyrimidine compound of formula (III). X=Cl, Br, or I. An INDEPENDENT CLAIM is included for compound (II), amino-protected cyclobutanone compound of formula (V), or sulfonylamino cyclobutanone compound of formula (IIa). Pg = protecting group; and Z1,Z2=1-4C alkyl, aryl, heteroaryl or heterocyclyl (all optionally substituted), or H; or Z1+Z2=5-6-membered cyclic ring.
IPC 分类号	A61K-031/519 ; C07D-487/04
国家	印度
专业领域	医药卫生
语种	英语
成果类型	专利
文献类型	科技成果
条目标识符	http://119.78.100.226:8889/handle/3KE4DYBR/20343
专题	中国科学院新疆生态与地理研究所
作者单位	MANKIND PHARMA LTD (MANK-Non-standard)
推荐引用方式 GB/T 7714	KUMAR N,CHATURVEDI V,BHAVSAR J,et al. Preparing abrocitinib for treating atopic dermatitis (eczema), comprises treating methylamino cyclobutane compound or its salt with 4-halo-7H-pyrrolo[2,3-d]pyrimidine compound. IN202311062811-A[P]. 2023.

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