METHOD OF PRODUCING BIOCOMPOSITE WITH ANTIBACTERIAL PROPERTIES
	PAPYNOV E K; SHICHALIN O O; APANASEVICH V I; KAPUSTINA O V
	2023-09-20
专利权人	UNIV MISIS NAT SCI & TECHNOLOGY (UMNS-C)
申请日期	2023-09-20
专利号	RU2824130-C1
成果简介	NOVELTY - Invention relates to a method of producing bioresorbable osteoplastic dispersed biocomposites of synthetic type, intended for treating diseases and injuries of the human bone system, and can be used in dentistry and maxillofacial surgery. Proposed method of producing a biocomposite with antibacterial properties based on wollastonite and hydroxyapatite involves preparing a reaction mixture, containing precursors—sodium metasilicate, calcium chloride, ammonium hydrophosphate and ammonium hydroxide in the form of aqueous solutions, in the form of a colloidal solution. Said colloidal solution is placed in an autoclave, heated until temperature reaches 180 °C, and held at said temperature for 6 hours. Obtained biocomposite in the form of an amorphous precipitate is separated, washed, dried and calcined at a heating rate of 10 °C/min until temperature reaches 800 °C, held at the achieved maximum temperature for 60 minutes. Obtained biocomposite of the crystalline composition is treated with a chitosan solution containing silver ions, after which the treated biocomposite is separated and dried in air at temperature of 20–25 °C for 1 hour. For the preparation of a chitosan solution containing silver ions, chitosan is dissolved in acetic acid, stirred at rate of 300 rpm for 6 hours, silver nitrate powder is added at a ratio of chitosan: acetic acid: silver nitrate powder of 0.4 g: 40 ml: 0.9 g, respectively, and the obtained mixture is boiled at 100 °C for 2 hours. USE - Medicine. ADVANTAGE - Simpler technology compared to the prototype by reducing the amount of reagents requiring more thorough burning from the volume of the biocomposite; obtaining a biocomposite having biocompatible and antibacterial properties. 3 cl, 2 tbl, 3 ex, 7 dwg
IPC 分类号	A61K-006/00 ; A61L-027/10 ; A61L-027/12 ; A61L-027/20 ; A61L-027/54 ; C04B-035/16 ; C04B-035/447
国家	俄罗斯
专业领域	材料科学
语种	英语
成果类型	专利
文献类型	科技成果
条目标识符	http://119.78.100.226:8889/handle/3KE4DYBR/20319
专题	中国科学院新疆生态与地理研究所
作者单位	UNIV MISIS NAT SCI & TECHNOLOGY (UMNS-C)
推荐引用方式 GB/T 7714	PAPYNOV E K,SHICHALIN O O,APANASEVICH V I,et al. METHOD OF PRODUCING BIOCOMPOSITE WITH ANTIBACTERIAL PROPERTIES. RU2824130-C1[P]. 2023.

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