| COMPLEX OF UREA DERIVATIVE WITH less than sup greater than 99m less than /sup greater than Tc RADIONUCLIDE LABEL FOR DIAGNOSIS OF TUMORS EXPRESSING PROSTATE-SPECIFIC MEMBRANE ANTIGEN, AND METHOD FOR PRODUCTION THEREOF | |
| 2023-09-20 | |
| 专利权人 | UNIV TOMSK POLYTECHNIC (UYTO-C) |
| 申请日期 | 2023-09-20 |
| 专利号 | RU2825402-C1 |
| 成果简介 | NOVELTY - Invention relates to a complex of a urea derivative with 99mTc radionuclide label for the diagnosis of tumors expressing a prostate-specific membrane antigen, 99mTc-(((1S)-5-((2S)-2-((2S)-2-(8-((2S)-2-acetamido-6-(2-(4-carboxy-2-(4-carboxy-2-(4-carboxy-2-(2-mercaptoacetamido)butanamido)butanamido)butanamido)acetamido)hexanamido)octanamido)-3-(4-hydroxyphenyl)propanamido)-3-(naphthalen-2-yl)propane-amido)-1-carboxypentyl)carbamoyl)-L-glutamic acid, presented by the structural formula given below. Also disclosed is a method of producing said complex of a derivative of urea with 99mTc radionuclide label. USE - Organic chemistry; medicine; oncology; pharmacology. ADVANTAGE - Wider range of complexes of urea derivatives with 99mTc radionuclide label for the diagnosis of tumors expressing a prostate-specific membrane antigen, with simultaneous increase in specific tumor uptake to (30±4) % and tumor:blood ratio to (38±14). 2 cl, 2 dwg, 1 tbl, 12 ex |
| IPC 分类号 | A61K-103/10 ; A61K-051/04 ; A61K-051/08 ; C07F-013/00 ; C07K-007/06 |
| 国家 | 俄罗斯 |
| 专业领域 | 生物科学 |
| 语种 | 英语 |
| 成果类型 | 专利 |
| 文献类型 | 科技成果 |
| 条目标识符 | http://119.78.100.226:8889/handle/3KE4DYBR/20311 |
| 专题 | 中国科学院新疆生态与地理研究所 |
| 作者单位 | UNIV TOMSK POLYTECHNIC (UYTO-C) |
| 推荐引用方式 GB/T 7714 | TOLMACHEV V M,ORLOVA A M,WITHOUT C A,et al. COMPLEX OF UREA DERIVATIVE WITH less than sup greater than 99m less than /sup greater than Tc RADIONUCLIDE LABEL FOR DIAGNOSIS OF TUMORS EXPRESSING PROSTATE-SPECIFIC MEMBRANE ANTIGEN, AND METHOD FOR PRODUCTION THEREOF. RU2825402-C1[P]. 2023. |
| 条目包含的文件 | 条目无相关文件。 | |||||
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