New functionalized cholesterol molecules comprising cholesterol backbone and functional group attached to 3beta-hydroxy, for preparing particulate pharmaceutical formulation, system for delivering therapeutic agents e.g. genetic materials for treating genetic disorders, used in e.g. gene silencing
	MITTAL A; ANSARI I; CHITKARA D
	2023-09-21
专利权人	BIRLA INST TECHNOLOGY & SCI PILANI (BIRL-Non-standard)
申请日期	2023-09-21
专利号	IN202311019415-A
成果简介	NOVELTY - Functionalized cholesterol molecules comprising a cholesterol backbone; and a functional group attached to the 3β-OH of the cholesterol backbone is new. USE - Functionalized cholesterol molecules for preparing particulate pharmaceutical formulation and system for delivering therapeutic agents such as genetic materials, peptides, proteins, and ribonucleoproteins for treating genetic disorders (all claimed); used in gene silencing, gene expression modulation, or gene editing. No biological data given. ADVANTAGE - The molecule improves interaction with cell membranes and enhances the efficacy of the drug delivery. DETAILED DESCRIPTION - INDEPENDENT CLAIMS are included for: a particulate pharmaceutical formulation comprises the functionalized cholesterol molecules and a therapeutic agent, where the formulation delivering therapeutic agents selected from genetic materials, peptides, proteins, and ribonucleoproteins; and a pharmaceutical carrier system comprising at least one functionalized cholesterol molecule.
IPC 分类号	A61K-031/70 ; A61K-047/00 ; C07C-229/00
国家	印度
专业领域	医药卫生
语种	英语
成果类型	专利
文献类型	科技成果
条目标识符	http://119.78.100.226:8889/handle/3KE4DYBR/20298
专题	中国科学院新疆生态与地理研究所
作者单位	BIRLA INST TECHNOLOGY & SCI PILANI (BIRL-Non-standard)
推荐引用方式 GB/T 7714	MITTAL A,ANSARI I,CHITKARA D. New functionalized cholesterol molecules comprising cholesterol backbone and functional group attached to 3beta-hydroxy, for preparing particulate pharmaceutical formulation, system for delivering therapeutic agents e.g. genetic materials for treating genetic disorders, used in e.g. gene silencing. IN202311019415-A[P]. 2023.

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