Preparing ferrostatin-1-loaded niosome for delivering ferrostatin-1 to targeted site, comprises preparing organic phase by dissolving polyoxyethylene sorbitan monooleate and cholesterol in ethyl alcohol comprising ferrostatin-1, preparing aqueous phase and injecting organic phase into aqueous phase
	SHARMA A; SRIVASTAVA N; YADAV A K; MAZAHIR F; GURJAR S
	2023-09-22
专利权人	NAT INST PHARM EDUCATION & RES (NAPH-Non-standard)
申请日期	2023-09-22
专利号	IN202311063873-A
成果简介	NOVELTY - Preparing ferrostatin-1 (FS-1)-loaded niosome comprises: (a) preparing organic phase by dissolving 180 mg Tween80 (RTM: Polyoxyethylene (20) sorbitan monooleate)and 14 mg cholesterol in 1 ml absolute ethyl alcohol comprising 2 mg/ml FS-1, and heating at 60℃; (b) preparing aqueous phase comprising 18.5 ml triple distilled water (TDW); and (c) slowly and uniformly injecting ~2 ml organic phase into the aqueous phase dropwise by syringe at 50℃ in a beaker under continuous magnetic stirring at 900 revolutions/minute using a magnetic stirrer, and stirring the dispersion for about 15 minutes till ethanol was evaporated, and the remaining was removed by evaporating under reduced pressure. USE - Method for preparing ferrostatin-1-loaded niosome for delivering ferrostatin-1 to targeted site for suppressing erastin-induced ferroptosis. Test details are described but no results given. ADVANTAGE - The method provides ferrostatin-1-loaded niosome with improved bioavailability and anti-ferroptotic activity, and stability. DETAILED DESCRIPTION - An INDEPENDENT CLAIM is included for ferrostatin-1-loaded niosomal formulation, which comprises 2 mg/ml FS-1, and Tween80 (RTM: Polyoxyethylene (20) sorbitan monooleate), Span60 (RTM: Sorbitan monostearate), and cholesterol in a ratio of 1:1:0.75.
IPC 分类号	A61K-036/899 ; A61K-047/24 ; A61K-047/28 ; A61K-009/127 ; A61P-027/02 ; A61P-035/00 ; A61P-009/00 ; A61P-009/10
国家	印度
专业领域	医药卫生
语种	英语
成果类型	专利
文献类型	科技成果
条目标识符	http://119.78.100.226:8889/handle/3KE4DYBR/20281
专题	中国科学院新疆生态与地理研究所
作者单位	NAT INST PHARM EDUCATION & RES (NAPH-Non-standard)
推荐引用方式 GB/T 7714	SHARMA A,SRIVASTAVA N,YADAV A K,et al. Preparing ferrostatin-1-loaded niosome for delivering ferrostatin-1 to targeted site, comprises preparing organic phase by dissolving polyoxyethylene sorbitan monooleate and cholesterol in ethyl alcohol comprising ferrostatin-1, preparing aqueous phase and injecting organic phase into aqueous phase. IN202311063873-A[P]. 2023.

条目包含的文件
条目无相关文件。

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。