Compound for treating cancer, comprises carbazole or phenoxyphenyl derivative, zinc-binding group, linker occupying hydrophobic tubular channel, and cap group consisting of bulkier aromatic groups selected from carbazoles, phenoxyphenyl, or naphthyl-2-oxyphenyl moieties
	KUMARI A; SHARMA N; MEHRA A; SANGWAN R
	2023-09-25
专利权人	UNIV LOVELY PROFESSIONAL (ULVP-C)
申请日期	2023-09-25
专利号	IN202311064116-A
成果简介	NOVELTY - Compound comprises a carbazole or phenoxyphenyl derivative, a zinc-binding group, a linker occupying a hydrophobic tubular channel, and a cap group consisting of bulkier aromatic groups selected from carbazoles, phenoxyphenyl, or naphthyl-2-oxyphenyl moieties. USE - Compound for treating cancer (claimed). No biological data given. ADVANTAGE - The compound is capable of chelating a zinc ion and inhibiting HDAC enzymatic activity, utilizes linker that enhances the compound's binding affinity to the histone deacetylases (HDAC) enzyme, utilizes zinc-binding group that provides increased potency in HDAC inhibition through effective chelation of the zinc ion in the enzyme's active site.
IPC 分类号	A61P-001/04 ; A61P-025/00 ; A61P-035/00 ; A61P-037/02 ; A61P-043/00
国家	印度
专业领域	医药卫生
语种	英语
成果类型	专利
文献类型	科技成果
条目标识符	http://119.78.100.226:8889/handle/3KE4DYBR/20263
专题	中国科学院新疆生态与地理研究所
作者单位	UNIV LOVELY PROFESSIONAL (ULVP-C)
推荐引用方式 GB/T 7714	KUMARI A,SHARMA N,MEHRA A,et al. Compound for treating cancer, comprises carbazole or phenoxyphenyl derivative, zinc-binding group, linker occupying hydrophobic tubular channel, and cap group consisting of bulkier aromatic groups selected from carbazoles, phenoxyphenyl, or naphthyl-2-oxyphenyl moieties. IN202311064116-A[P]. 2023.

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