| Formulation (Cu-HA-Au-PMNPs) for used in targeted tissues and cells for imaging, and for therapy, comprises superparamagnetic iron oxide nanoparticle (SPION) having SPIONs stabilized with polyethyleneimine (PEI) surface coating, where PEI layer functionalized with gold, copper-63 and hyaluronic acid | |
| 2023-09-25 | |
| 专利权人 | MANIPAL ACAD HIGHER EDUCATION (MANI-Non-standard) |
| 申请日期 | 2023-09-25 |
| 专利号 | IN202341064268-A |
| 成果简介 | NOVELTY - Formulation (Cu-HA-Au-PMNPs) comprises: a superparamagnetic iron oxide nanoparticle (SPION) comprising SPIONs stabilized with 0.002-0.012 wt.% polyethyleneimine (PEI) surface coating, and the PEI layer functionalized with Gold (Au), copper (Cu) (II)-63, and 0.045 wt.% hyaluronic acid (HA) having 25.58-27.44 wt.% iron (Fe), 49.11-52.16 wt.% Au and 0.00047-0.0047 wt.% copper (Cu). USE - Formulation used as contrast agent and theragnostic agent formulation to sensitize cancer cells for radionuclide therapy (all claimed), and for selectively delivering drugs, e.g., Cu-64, a theragnostic radionuclide to cells, for killing cells in tumors, metastasis and micrometastasis. No biological data given. ADVANTAGE - The formulation helps in enhancing non-invasive imaging. DETAILED DESCRIPTION - An INDEPENDENT CLAIM is included for a method of preparing the formulation, which involves: (a) preparing a SPION using a mixture of ferric chloride hexahydrate (FeCl3.6H2O) and ferric chloride tetrahydrate (FeCl2.4H2O) by co-precipitation method; (b) stabilizing the surface of SPION by adsorbing PEI on SPIONs (PMNPs); (c) coating gold particles to the surface of PMNPs, followed by coating 3 additional layers of gold to obtain Au-PMNPs; (d) functionalizing Au-PMNPs using HA by covalent conjugation of HA to PEI in Au-PMNPs (HA-Au-PMNPs); and (e) conjugating copper with HA-Au-PMNPs by Cu-II complexation with HA or PEI of the HA-Au-PMNPs to obtain the Cu-HA-AuPMNPs formulation. |
| IPC 分类号 | A61K-049/04 ; A61K-049/06 ; A61K-049/12 ; A61K-049/18 ; A61K-009/14 ; B82Y-030/00 ; G01N-024/00 |
| 国家 | 印度 |
| 专业领域 | 医药卫生 |
| 语种 | 英语 |
| 成果类型 | 专利 |
| 文献类型 | 科技成果 |
| 条目标识符 | http://119.78.100.226:8889/handle/3KE4DYBR/20256 |
| 专题 | 中国科学院新疆生态与地理研究所 |
| 作者单位 | MANIPAL ACAD HIGHER EDUCATION (MANI-Non-standard) |
| 推荐引用方式 GB/T 7714 | SHRIDHARAN V,RAVIRAJ N,MUTALIK S,et al. Formulation (Cu-HA-Au-PMNPs) for used in targeted tissues and cells for imaging, and for therapy, comprises superparamagnetic iron oxide nanoparticle (SPION) having SPIONs stabilized with polyethyleneimine (PEI) surface coating, where PEI layer functionalized with gold, copper-63 and hyaluronic acid. IN202341064268-A[P]. 2023. |
| 条目包含的文件 | 条目无相关文件。 | |||||
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