Piroxicam-loaded elastic niosomes for treating inflammatory conditions such as edema,
	KAURAV H; SHARMA A; KAPOOR D
	2023-09-26
专利权人	UNIV SHOOLINI BIOTECHNOLOGY & MANAGEMENT (USLN-C)
申请日期	2023-09-26
专利号	IN202311064386-A
成果简介	NOVELTY - Piroxicam-loaded elastic niosomes comprise 0.4-1.3 g Span(RTM: Sorbitan monostearate) 60, 350-800 mg cholesterol, 2-3 ml ethanol, 2- 4 ml chloroform, 60 mg piroxicam, 6-12 ml buffer, and 0.5 wt.% Carbopol(RTM: Crosslinked acrylic acid polymer) 940, where the Span(RTM: Sorbitan monostearate) 60 and cholesterol is in a ratio selected from 1:1, 2:1, 3:1 and 3:2. USE - Piroxicam-loaded elastic niosomes for treating inflammatory conditions such as edema. No biological data given. ADVANTAGE - The piroxicam-loaded elastic niosomes gel exhibit edema amelioration efficacy upto 53%, exhibit an antiinflammatory activity of 48.79% and in-vivo drug permeation of 68.05%, exhibit firmness consistency, cohesiveness, and an index of viscosity as 236.89, 203.28, -135.82 and -83.73 respectively, and exhibit optimized particle size, stability, and user-friendly physical properties. DETAILED DESCRIPTION - An INDEPENDENT CLAIM is included for a method for preparing piroxicam-loaded elastic niosomes, comprising: (a) dissolving 0.4-1.3 g Span (RTM: Sorbitan monostearate) 60 and 350-800 mg cholesterol in a ratio selected from 1:1, 2:1, 3:1, 3:2 in a 3 ml chloroform:ethanol mixture volume ratio of 2:1; (b) subjecting the mixture from step (a) to a rotary evaporator for 30 minutes under reduced pressure until a thin film is formed; (c) hydrating the thin film by adding 6 ml phosphate buffer saline (PBS) of pH 7.4 containing 1.2 ml of ethanol and rotary evaporating the mixture at 200 rpm for one hour under atmospheric pressure until a milky dispersion is produced; or (a1) dissolving 0.4-1.3 g Span (RTM: Sorbitan monostearate) 60 and 350-800 mg cholesterol in a ratio selected from 1:1, 2:1, 3:1, 3:2 in a 3 ml chloroform:ethanol mixture having volume ratio of 2:1; (b1) injecting the solution into a preheated aqueous phase containing piroxicam at a concentration of 10 mg/ml in a hydroalcoholic solution of 20% ethanol/80% PBS of pH 7.4 and maintained at 60℃; (c1) continuously stirring the resulting mixture by using a magnetic stirrer for an additional 30 minutes post-injection at room temperature; or (a2) dispensing the gel containing 0.5 wt.% Carbopol(RTM: Crosslinked acrylic acid polymer) 940 into a niosomal dispersion; (b2) stirring the mixture till the total piroxicam concentration in the resulting gel is equal to 0.5 wt.% ; (c2) adjusting the pH of the gel to 7 using triethanolamine.
IPC 分类号	A61K-009/00 ; A61P-011/00 ; A61P-017/06 ; A61P-019/02 ; A61P-029/00
国家	印度
专业领域	医药卫生
语种	英语
成果类型	专利
文献类型	科技成果
条目标识符	http://119.78.100.226:8889/handle/3KE4DYBR/20244
专题	中国科学院新疆生态与地理研究所
作者单位	UNIV SHOOLINI BIOTECHNOLOGY & MANAGEMENT (USLN-C)
推荐引用方式 GB/T 7714	KAURAV H,SHARMA A,KAPOOR D. Piroxicam-loaded elastic niosomes for treating inflammatory conditions such as edema,. IN202311064386-A[P]. 2023.

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