Preparing omidenepag isopropyl compound used in preparation of medicine for treating elevated intraocular pressure in patients, comprises reacting N-{[4-(1H-pyrazol-1-yl)phenyl]methyl}-N-[(pyridin-2-yl)methyl]pyridine-3-sulfonamide compound with acetate compound in presence of base and solvent
	NAMBIAR S; GNANAPRAGASAM S; NAGAPPAN N; PALANIVEL S; ARJUNAN S
	2023-09-26
专利权人	SOLARA ACTIVE PHARMA SCI LTD (SOLA-Non-standard)
申请日期	2023-09-26
专利号	IN202341064703-A
成果简介	NOVELTY - Preparing omidenepag isopropyl compound (I) comprises: reacting N-{[4-(1H-pyrazol-1-yl)phenyl]methyl}-N-[(pyridin-2-yl)methyl]pyridine-3-sulfonamide compound (III) with acetate compound (II) in the presence of a base and a solvent to obtain a compound (I). USE - Method for preparing omidenepag isopropyl compound used in preparation of medicament for treating elevated intraocular pressure in patients (all claimed). No biological data given. ADVANTAGE - The compound (I) has purity of more than 99% by HPLC, and is simple at a large scale production with economically significance. DETAILED DESCRIPTION - Preparing omidenepag isopropyl compound of formula (I) comprises: reacting N-{[4-(1H-pyrazol-1-yl)phenyl]methyl}-N-[(pyridin-2-yl)methyl]pyridine-3-sulfonamide compound of formula (III) with a acetate compound of formula (II) in the presence of a base and a solvent to obtain a compound (I). R1=an amino protecting group, preferably 9-Fluorenylmethyloxycarbonylation (Fmoc), tertButoxycarbonylation (Boc) reagents, Allyloxycarbonylation (Alloc) reagents, Benzyloxycarbonylation (Cbz) reagents, Benzylation (Bn) reagents, Allylation (All) reagents and 2,2,2-Trichloroethoxycarbonylation (Troc) reagents; and X=halogen group selected from iodo, chloro, fluoro and bromo groups. INDEPENDENT CLAIMS are included for: 1. a process for preparation of compound of formula (IV) comprising: reacting compound (VI) with compound (V) in the presence of a base and a solvent to form a compound (IV); and 2. a composition of omidenepag isopropyl comprising the impurity-A, of less than 0.1% by HPLC.
IPC 分类号	A61K-031/138 ; A61P-023/02 ; A61P-025/04 ; C07B-061/00 ; C07C-213/02 ; C07C-213/06 ; C07C-217/20 ; C07D-401/14
国家	印度
专业领域	医药卫生
语种	英语
成果类型	专利
文献类型	科技成果
条目标识符	http://119.78.100.226:8889/handle/3KE4DYBR/20234
专题	中国科学院新疆生态与地理研究所
作者单位	SOLARA ACTIVE PHARMA SCI LTD (SOLA-Non-standard)
推荐引用方式 GB/T 7714	NAMBIAR S,GNANAPRAGASAM S,NAGAPPAN N,et al. Preparing omidenepag isopropyl compound used in preparation of medicine for treating elevated intraocular pressure in patients, comprises reacting N-{[4-(1H-pyrazol-1-yl)phenyl]methyl}-N-[(pyridin-2-yl)methyl]pyridine-3-sulfonamide compound with acetate compound in presence of base and solvent. IN202341064703-A[P]. 2023.

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