Synthesizing indole-quinoline derivative in inhibiting angiogenesis, and treating diseases of abnormal blood vessel growth, comprises taking mixture of sodium hydride as a strong base with dimethylformamide and indole carbaldehyde, refluxing, and reacting with pyruvic acid and trimethoxy aniline
	DHIMAN N; SRIVASTAVA N; MISHRA S; NIMESH H
	2023-09-27
专利权人	UNIV AMITY (UAMI-C)
申请日期	2023-09-27
专利号	IN202311064892-A
成果简介	NOVELTY - Synthesizing indole-quinoline derivative comprises taking mixture of sodium hydride as a strong base with 10 mL of dimethylformamide and indole-3-carbaldehyde and substituted halides, refluxing the mixture for 6 hours while stirring to obtain N-substituted indole-3-carbaldehyde derivative (I), reacting with pyruvic acid and 3,4,5-trimethoxyaniline at 80 ℃ for 3 hours in ethanol as a solvent using a Dobner reaction procedure; and isolating the final products 5,6,7-trimethoxy-2-indolylquinoline-4-carboxylic acid derivatives as compounds 1 and 3 in solid form. USE - Method for synthesizing indole-quinoline derivative in inhibiting angiogenesis, and treating diseases caused by abnormal blood vessel growth. No biological data given. ADVANTAGE - The method provides product with increased specificity, better patient compliance, and lower side effects along with reduction in chemo-resistance. DETAILED DESCRIPTION - Synthesizing indole-quinoline derivative comprises taking mixture of sodium hydride as a strong base with 10 mL of dimethylformamide and indole-3-carbaldehyde and substituted halides, refluxing the mixture for 6 hours while stirring to obtain N-substituted indole-3-carbaldehyde derivative of formula (I), reacting with pyruvic acid and 3,4,5-trimethoxyaniline at 80 ℃ for 3 hours in ethanol as a solvent using a Dobner reaction procedure; and isolating the final products as 5,6,7-trimethoxy-2-indolylquinoline-4-carboxylic acid derivatives as compounds 1 and 3 in solid form, where R=benzyl, p-methoxybenzyl, propyl, isopropyl, and butyl. An INDEPENDENT CLAIM is included for an indole-quinoline derivative of formula (II), which is new. R=methyl, ethyl, benzyl, p-methoxybenzyl, propyl, isopropyl, and butyl.
IPC 分类号	A61K-031/437 ; A61P-035/00 ; C07C-069/732 ; C07D-207/06 ; C07D-209/08 ; C07D-239/88 ; C07D-403/12 ; C07D-471/04
国家	印度
专业领域	医药卫生
语种	英语
成果类型	专利
文献类型	科技成果
条目标识符	http://119.78.100.226:8889/handle/3KE4DYBR/20221
专题	中国科学院新疆生态与地理研究所
作者单位	UNIV AMITY (UAMI-C)
推荐引用方式 GB/T 7714	DHIMAN N,SRIVASTAVA N,MISHRA S,et al. Synthesizing indole-quinoline derivative in inhibiting angiogenesis, and treating diseases of abnormal blood vessel growth, comprises taking mixture of sodium hydride as a strong base with dimethylformamide and indole carbaldehyde, refluxing, and reacting with pyruvic acid and trimethoxy aniline. IN202311064892-A[P]. 2023.

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