| Preparing 1-methyl-4-(piperidin-4-yl)piperazine useful as intermediates in preparation of Brigatinib, involves reductive amination of piperidin-4-one compound with 1-methylpiperizine to give 1-methyl-4-(piperidin-4-yl)piperazine compound followed by hydrolyzing | |
| 2023-09-30 | |
| 专利权人 | VASUDHA PHARMA CHEM LTD (VASU-Non-standard) |
| 申请日期 | 2023-09-30 |
| 专利号 | IN202341065872-A |
| 成果简介 | NOVELTY - The process for the preparation of 1-methyl-4-(piperidin-4-yl)piperazine (V) involves: reductive amination of piperidin-4-one compound (II) with 1-methylpiperizine (III) to give 1-methyl-4-(piperidin-4-yl)piperazine compound (IV) and then hydrolyzing the compound (IV). USE - Process for the preparation of 1-methyl-4-(piperidin-4-yl)piperazine (V) which is useful as intermediates in the preparation of Brigatinib. ADVANTAGE - The process exhibits very least experimental error, technique error and instrument error. DETAILED DESCRIPTION - The process for the preparation of 1-methyl-4-(piperidin-4-yl)piperazine of formula (V) involves: reductive amination of piperidin-4-one compound of formula (II) with 1-methylpiperizine of formula (III) to give 1-methyl-4-(piperidin-4-yl)piperazine compound of formula (IV) and then hydrolyzing the compound (IV). (R = 1-3C-alkyl). An INDEPENDENT CLAIM is included for the 1-methyl-4-(piperidin-4-yl)piperazine compound (IV). |
| IPC 分类号 | C07D-213/74 |
| 国家 | 印度 |
| 专业领域 | 医药卫生 |
| 语种 | 英语 |
| 成果类型 | 专利 |
| 文献类型 | 科技成果 |
| 条目标识符 | http://119.78.100.226:8889/handle/3KE4DYBR/20172 |
| 专题 | 中国科学院新疆生态与地理研究所 |
| 作者单位 | VASUDHA PHARMA CHEM LTD (VASU-Non-standard) |
| 推荐引用方式 GB/T 7714 | POTNURU E R,RAMBA S,BOJJA V R,et al. Preparing 1-methyl-4-(piperidin-4-yl)piperazine useful as intermediates in preparation of Brigatinib, involves reductive amination of piperidin-4-one compound with 1-methylpiperizine to give 1-methyl-4-(piperidin-4-yl)piperazine compound followed by hydrolyzing. IN202341065872-A[P]. 2023. |
| 条目包含的文件 | 条目无相关文件。 | |||||
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