Pharmaceutical composition used for treating thromboembolic disorders, comprises rivaroxaban, mannitol, anhydrous citric acid, hypromellose, sodium benzoate, combination of xanthan gum and mixture of microcrystalline cellulose and carboxymethylcellulose sodium, sucralose, flavoring agent, excipients
	SINGH S; SHIROLE Y; WAGH K; PRADHAN M; TALLAM S; PANDEY A K
	2023-10-04
专利权人	ALKEM LAB LTD (ALKE-Non-standard)
申请日期	2023-10-04
专利号	IN202321066401-A
成果简介	NOVELTY - Pharmaceutical composition comprises: (a) 0.5-10 wt.% rivaroxaban or its salt; (b) 50-80 wt.% mannitol; (c) 1-5 wt.% anhydrous citric acid; (d) 0.5-3 wt.% hypromellose; (e) 1-8 wt.% sodium benzoate; (f) 10-30 wt.% combination of xanthan gum, and mixture of microcrystalline cellulose and carboxymethylcellulose sodium; (g) 0.5-3 wt.% sucralose; (h) 0.5-3 wt.% flavoring agent; and optionally other its excipients. USE - Pharmaceutical composition used for treating thromboembolic disorder, or venous thromboembolism (VTE); and reducing risk of recurrent VTE in pediatric patients from birth to less than 18 years and for thromboprophylaxis in pediatric patients 2 years and older with congenital heart disease after the Fontan procedure. Test details are described but no results given. ADVANTAGE - The pharmaceutical composition has improved stability, and easy to swallow to children. DETAILED DESCRIPTION - An INDEPENDENT CLAIM is included for a method of preparing a pharmaceutical composition, which involves: using wet granulation process.
IPC 分类号	A61J-003/07 ; A61K-031/5377 ; A61K-009/51
国家	印度
专业领域	医药卫生
语种	英语
成果类型	专利
文献类型	科技成果
条目标识符	http://119.78.100.226:8889/handle/3KE4DYBR/20130
专题	中国科学院新疆生态与地理研究所
作者单位	ALKEM LAB LTD (ALKE-Non-standard)
推荐引用方式 GB/T 7714	SINGH S,SHIROLE Y,WAGH K,et al. Pharmaceutical composition used for treating thromboembolic disorders, comprises rivaroxaban, mannitol, anhydrous citric acid, hypromellose, sodium benzoate, combination of xanthan gum and mixture of microcrystalline cellulose and carboxymethylcellulose sodium, sucralose, flavoring agent, excipients. IN202321066401-A[P]. 2023.

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