Albumin-coated nanoparticle for targeted drug delivery of anticancer drug for treating cancer, comprises bovine serum albumin for aqueous media, and Myrica esculenta extract, where nanoparticles exhibit specified mean particle size
	KUMAR D; SINGH J; SHUKLA M K
	2023-10-06
专利权人	UNIV SHOOLINI BIOTECHNOLOGY & MANAGEMENT (USLN-C)
申请日期	2023-10-06
专利号	IN202311066979-A
成果简介	NOVELTY - Albumin-coated nanoparticle comprises bovine serum albumin (BSA) 200 mg for 100 ml aqueous media, and Myrica esculenta (M.E.) extract, where the ratio of Myrica esculenta extract and BSA is 1:10. The nanoparticles exhibit mean particle size of 150-200 nm. USE - Albumin-coated nanoparticle for targeted drug delivery of anticancer drug for treating cancer, and inhibiting cancer cell growth. ADVANTAGE - The albumin-coated nanoparticle ensures enhanced drug efficacy, reduced side effects against HCT116 cancer cell lines, while exhibiting no cytotoxicity towards normal cells, and improved anti-proliferative activity against HCT-116 cancer cell lines. DETAILED DESCRIPTION - An INDEPENDENT CLAIM is included for a method for preparing nanoparticle, which comprises: (a) collecting Myrica esculenta plant's bark and drying; (b) converting the bark of step (a) into coarse particle form; (c) extracting the coarse particle with methanol; (d) drying the methanolic extract of step (c); (e) dissolving the dried extract of step (d) in methanol.; (f) adding methanol solution of step (e) to water containing BSA in a ratio of 1:10 in a dropwise manner while heating and stirring at 700 revolutions/minute for 4 hours to obtain spherical nanoparticles; and (g) centrifuging at 1200 revolutions/minute for 10minutes at 4℃ to the solution of step (f), and lyophilizing for further use.
IPC 分类号	A61K-036/185 ; A61K-047/69 ; A61K-049/00 ; A61K-009/51 ; A61P-035/00
国家	印度
专业领域	医药卫生
语种	英语
成果类型	专利
文献类型	科技成果
条目标识符	http://119.78.100.226:8889/handle/3KE4DYBR/20112
专题	中国科学院新疆生态与地理研究所
作者单位	UNIV SHOOLINI BIOTECHNOLOGY & MANAGEMENT (USLN-C)
推荐引用方式 GB/T 7714	KUMAR D,SINGH J,SHUKLA M K. Albumin-coated nanoparticle for targeted drug delivery of anticancer drug for treating cancer, comprises bovine serum albumin for aqueous media, and Myrica esculenta extract, where nanoparticles exhibit specified mean particle size. IN202311066979-A[P]. 2023.

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