New nucleic acid construct comprising its nucleotide sequence, for binding to heat shock protein 90-alpha isoform
2023-10-13
专利权人NAT INST PHARM EDUCATION & RES (NAPH-Non-standard)
申请日期2023-10-13
专利号IN202311068998-A
成果简介NOVELTY - Nucleic acid construct is new, where nucleic acid construct has nucleotide sequence selected from sequences comprising 75 nucleobases of (SEQ ID NOs: 1-7), given in the specification. USE - Nucleic acid construct for binding to heat shock protein 90-alpha isoform. ADVANTAGE - The construct binds to alpha isoform of the HSP90 with high affinity (Kd) in the range of 99 nM to 1.2 μM or 113 nM to 5 μM for HSP90 alpha isoform. The inhibitor against the N20 terminal domain of only HSP90α eliminate its side effects. DETAILED DESCRIPTION - An INDEPENDENT CLAIM is included for method for preparation of nucleic acid construct for binding to HSP90-alpha isoform.
IPC 分类号A61K-038/00 ; C07K-014/00 ; C07K-014/435 ; C07K-014/47
国家印度
专业领域医药卫生
语种英语
成果类型专利
文献类型科技成果
条目标识符http://119.78.100.226:8889/handle/3KE4DYBR/19972
专题中国科学院新疆生态与地理研究所
作者单位
NAT INST PHARM EDUCATION & RES (NAPH-Non-standard)
推荐引用方式
GB/T 7714
KAUR J,ROY I. New nucleic acid construct comprising its nucleotide sequence, for binding to heat shock protein 90-alpha isoform. IN202311068998-A[P]. 2023.
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