Preparing oxime compound used for midazolam preparation, involves reacting 2-amino-5-chloro-2'-fluorobenzophenone, hydroxylamine hydrochloride in enhancing agent in polar solvent to obtain benzophenone-beta-oxime derivative, in-situ treating with chloroacetyl chloride, base or non-polar solvent
	TRIPATHI A P; RAIKWAR D K; PAWAR M P; NAIK A M; SAWANT S D
	2023-10-18
专利权人	CENTAUR PHARM PVT LTD (CENT-Non-standard)
申请日期	2023-10-18
专利号	IN202321070829-A
成果简介	NOVELTY - Preparing oxime compound of (I), involves: (i) reacting 2-amino-5-chloro-2'-fluorobenzophenone compound of (V) with hydroxylamine hydrochloride in presence of enhancing agent in polar solvent to obtain 2-amino-5-chloro-2'-fluorobenzophenone-β-oxime compound of (XVIII), which is in-situ treated with chloroacetyl chloride in presence of base in non-polar solvent to obtain oxime compound (I). USE - Process for preparing oxime compound used for the preparation of midazolam compound (claimed), as sedative and inductive agent. ADVANTAGE - The process is efficient, economical, eco-friendly, simple, cost-efficient and environment friendly, and exhibits high yield and purity. DETAILED DESCRIPTION - Preparing oxime compound of formula (I), involves: (i) reacting 2-amino-5-chloro-2'-fluorobenzophenone compound of formula (V) with hydroxylamine hydrochloride in presence of enhancing agent in polar solvent to obtain 2-amino-5-chloro-2'-fluorobenzophenone-β-oxime compound of formula (XVIII), which is in-situ treated with chloroacetyl chloride in presence of base in non-polar solvent to obtain oxime compound (I). An INDEPENDENT CLAIM is included for a use of oxime compound (I) obtained by the process, which is provided for the preparation of midazolam compound of formula (II).
IPC 分类号	C07C-257/06 ; C07C-271/20 ; C07D-207/06 ; C07D-211/14 ; C07D-239/76 ; C07D-243/16 ; C07D-243/20 ; C07D-487/04
国家	印度
专业领域	医药卫生
语种	英语
成果类型	专利
文献类型	科技成果
条目标识符	http://119.78.100.226:8889/handle/3KE4DYBR/19492
专题	中国科学院新疆生态与地理研究所
作者单位	CENTAUR PHARM PVT LTD (CENT-Non-standard)
推荐引用方式 GB/T 7714	TRIPATHI A P,RAIKWAR D K,PAWAR M P,et al. Preparing oxime compound used for midazolam preparation, involves reacting 2-amino-5-chloro-2'-fluorobenzophenone, hydroxylamine hydrochloride in enhancing agent in polar solvent to obtain benzophenone-beta-oxime derivative, in-situ treating with chloroacetyl chloride, base or non-polar solvent. IN202321070829-A[P]. 2023.

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