Preparing azoxystrobin used as pesticides and fungicides in foliar application and in seed treatment, involves reacting 2-(6-chloropyrimidin-4-yloxy) phenyl derivative with 2-cyanophenol compound in the presence of (1,4-Diazabicyclo[2.2.2]octan-2-yl)methanol or salts/derivatives
	SHELKE S G; TOTRE J; KINI P
	2023-10-20
专利权人	UPL LTD (UPHL-C)
申请日期	2023-10-20
专利号	IN202321071802-A
成果简介	NOVELTY - Preparing azoxystrobin, involves: (a) reacting 2-(6-chloropyrimidin-4-yloxy) phenyl derivative of (IV) with 2-cyanophenol compound of (V) in presence of (1,4-Diazabicyclo[2.2.2]octan-2-yl)methanol or salts/derivatives; or (b) reacting 3-(methoxymethylene) benzofuran-2(3H)-one of (II) with 4,6-dichloropyrimidine of (III) in presence of (1,4-Diazabicyclo [2.2.2] octan-2-yl) methanol or salts/derivatives to get 2-(6-chloropyrimidin-4-yloxy) phenyl derivative of (IV); and reacting 2-(6-chloropyrimidin-4-yloxy) phenyl derivative (IV) with 2-cyanophenol (V) in presence of (1,4-Diazabicyclo[2.2.2]octan-2-yl)methanol or salts/derivatives to obtain azoxystrobin; or (c) reacting a 3-(methoxymethylene) benzofuran-2(3H)-one (II) with 2-[(6-Chloro-4-pyrimidinyl)oxy]benzonitrile of (VI) in presence of (1,4-Diazabicyclo[2.2.2]octan-2-yl)methanol or salts/derivatives. USE - Process for preparing azoxystrobin used as pesticides and fungicides in foliar application and in seed treatment. No biological data given. ADVANTAGE - The process exhibits high yield and purity; economical, simple and substantially free of undesired isomer; and avoids the usage of large volumes of highly polar solvents such as dimethylacetamide, dimethyl sulfoxide, dimethylformamide and N-methyl-2-pyrrolidone. DETAILED DESCRIPTION - Preparing azoxystrobin, involves: (a) reacting 2-(6-chloropyrimidin-4-yloxy) phenyl derivative of formula (IV) with 2-cyanophenol compound of formula (V) in presence of (1,4-Diazabicyclo[2.2.2]octan-2-yl)methanol or salts/derivatives; or (b) reacting 3-(methoxymethylene) benzofuran-2(3H)-one of formula (II) with 4,6-dichloropyrimidine of formula (III) in presence of (1,4-Diazabicyclo [2.2.2] octan-2-yl) methanol or salts/derivatives to get 2-(6-chloropyrimidin-4-yloxy) phenyl derivative of formula (IV); and reacting 2-(6-chloropyrimidin-4-yloxy) phenyl derivative (IV) with 2-cyanophenol (V) in presence of (1,4-Diazabicyclo[2.2.2]octan-2-yl)methanol or salts/derivatives to obtain azoxystrobin; or (c) reacting a 3-(methoxymethylene) benzofuran-2(3H)-one (II) with 2-[(6-Chloro-4-pyrimidinyl)oxy]benzonitrile of formula (VI) in presence of (1,4-Diazabicyclo[2.2.2]octan-2-yl)methanol or salts/derivatives. Q=methyl (E)-2-(3-methoxy) acrylate, and methyl 2-(3,3-dimethoxy) propanoate. An INDEPENDENT CLAIM is included for a process for preparation of 2-(6-chloropyrimidin-4-yloxy) phenyl derivative of formula (IV).
IPC 分类号	A01N-043/54 ; C07C-067/20 ; C07C-067/31 ; C07D-239/34 ; C07D-239/52
国家	印度
专业领域	化学化工
语种	英语
成果类型	专利
文献类型	科技成果
条目标识符	http://119.78.100.226:8889/handle/3KE4DYBR/19475
专题	中国科学院新疆生态与地理研究所
作者单位	UPL LTD (UPHL-C)
推荐引用方式 GB/T 7714	SHELKE S G,TOTRE J,KINI P. Preparing azoxystrobin used as pesticides and fungicides in foliar application and in seed treatment, involves reacting 2-(6-chloropyrimidin-4-yloxy) phenyl derivative with 2-cyanophenol compound in the presence of (1,4-Diazabicyclo[2.2.2]octan-2-yl)methanol or salts/derivatives. IN202321071802-A[P]. 2023.

条目包含的文件
条目无相关文件。

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。