| CONJUGATE BASED ON MAGNETIC NANOPARTICLES FOR THERAPY OF SOLID TUMORS AND METHOD FOR PREPARATION THEREOF | |
| 2023-11-01 | |
| 专利权人 | POSTOVSKY ORGANIC SYNTHESIS INST (POST-Soviet Institute) ; UNIV SIBE MEDICAL (UYSI-Non-standard) |
| 申请日期 | 2023-11-01 |
| 专利号 | RU2830006-C1 |
| 成果简介 | NOVELTY - Invention relates to biotechnology and medicine, specifically to a nanoconjugate for therapy of malignant solid tumours and a method for obtaining thereof. Nanoconjugate includes nanosized particle of iron oxide and anticancer preparation doxorubicin, wherein nanosized magnetic particle of iron oxide FenFe3-nO4, where 0 ≤ n ≤ 1 is coated with a layer of SiO2functionalised with 3-aminopropylsilane, covalently bonded to SiO2 and molecules of bifunctional polyethylene glycol with molar weight from 1,000 to 10,000 Da with terminal carboxyl groups. Method of producing the nanoconjugate consists in depositing iron oxide on a nanosized magnetic particle FenFe3-nO4, where 0 ≤ n ≤ 1, layer of SiO2 using tetramethylorthosilicate (TMOS) or tetraethoxysilane (TEOS), its modification with (3-aminopropyl) trimethoxysilane (APTMS) or (3-aminopropyl) triethoxysilane (APTES), subsequent covalent bonding with molecules of bifunctional polyethylene glycol with a molar weight of 1,000 to 10,000 Da with terminal carboxyl groups due to formation of an amide bond and fixation on the surface of the anticancer preparation doxorubicin. There is also a possibility of monitoring its distribution in the tumour by MRI. USE - Biotechnology; medicine. ADVANTAGE - Disclosed nanoconjugate enables therapy of malignant solid tumours by combining the effect of local hyperthermia (when using an alternating magnetic field) and chemotherapy (due to the presence of an anticancer drug in the nanoconjugate). 2 cl, 9 dwg, 4 tbl, 6 ex |
| IPC 分类号 | A61K-047/02 ; A61K-047/10 ; A61P-035/00 ; B82B-003/00 ; B82Y-005/00 |
| 国家 | 俄罗斯 |
| 专业领域 | 化学化工 |
| 语种 | 英语 |
| 成果类型 | 专利 |
| 文献类型 | 科技成果 |
| 条目标识符 | http://119.78.100.226:8889/handle/3KE4DYBR/19387 |
| 专题 | 中国科学院新疆生态与地理研究所 |
| 作者单位 | 1.POSTOVSKY ORGANIC SYNTHESIS INST (POST-Soviet Institute) 2.UNIV SIBE MEDICAL (UYSI-Non-standard) |
| 推荐引用方式 GB/T 7714 | DYOMIN A M,VAKHRUSHEV A V,VALOVA M S,et al. CONJUGATE BASED ON MAGNETIC NANOPARTICLES FOR THERAPY OF SOLID TUMORS AND METHOD FOR PREPARATION THEREOF. RU2830006-C1[P]. 2023. |
| 条目包含的文件 | 条目无相关文件。 | |||||
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