| PYRIMIDINE DERIVATIVES - INHIBITORS OF REPRODUCTION OF VIRUSES RELATED TO GENUS ORTHOFLAVIVIRUS | |
| 2023-11-02 | |
| 专利权人 | ROBOTICS & TECH CYBERNETICS CENT RES (ROBO-Non-standard) ; FEDERAL STATE BUDGETARY EDUCATIONAL (BUDG-Non-standard) |
| 申请日期 | 2023-11-02 |
| 专利号 | RU2831118-C1 |
| 成果简介 | NOVELTY - Invention relates to organic and medicinal chemistry, pharmacology and medicine, specifically to a compound of general formula (I) or a pharmaceutically acceptable salt thereof, where R1 is selected independently and represents: NH-(C1-5-alkyl)-(1-adamantyl); NH-(C1-5-alkyl)-(2-adamantyl); NH-(C1-5-alkyl)-OH; ; R2 is selected independently and represents: C3-6-cycloalkyl, isopropyl, alternatively R2 is methyl, if R1 is ; n takes values 0-2. Invention also relates to a compound of general formula (II) or a pharmaceutically acceptable salt thereof, where if R'1 is selected independently and represents: NH-(C1-5-alkyl)-(1-adamantyl); NH-(C1-5-alkyl)-(2-adamantyl); then R'2 is selected independently and represents hydrogen, methyl, -NH2, halogen; alternatively, if R'1 is selected independently and represents: ; ; ; then R'2 is selected independently and represents methyl, -NH2, halogen; n takes values 0-2. Invention also relates to a pharmaceutical composition based on said compounds and use thereof as an inhibitor of reproduction of a virus belonging to the genus Orthoflavivirus. USE - Chemistry. ADVANTAGE - Design and production of compounds characterized by high efficiency in inhibiting reproduction of viruses of the genus Orthoflavivirus, particularly tick-borne encephalitis virus, yellow fever virus, West Nile virus and others. 11 cl, 4 tbl |
| IPC 分类号 | A61K-031/517 ; A61P-031/14 ; C07D-239/88 ; C07D-239/90 ; C07D-239/94 ; C07D-239/95 ; C07D-403/12 |
| 国家 | 俄罗斯 |
| 专业领域 | 化学化工 |
| 语种 | 英语 |
| 成果类型 | 专利 |
| 文献类型 | 科技成果 |
| 条目标识符 | http://119.78.100.226:8889/handle/3KE4DYBR/19372 |
| 专题 | 中国科学院新疆生态与地理研究所 |
| 作者单位 | 1.ROBOTICS & TECH CYBERNETICS CENT RES (ROBO-Non-standard) 2.FEDERAL STATE BUDGETARY EDUCATIONAL (BUDG-Non-standard) |
| 推荐引用方式 GB/T 7714 | AVERINA E B,GORYASHCHENKO A S,ISHMUKHAMETOV A A,et al. PYRIMIDINE DERIVATIVES - INHIBITORS OF REPRODUCTION OF VIRUSES RELATED TO GENUS ORTHOFLAVIVIRUS. RU2831118-C1[P]. 2023. |
| 条目包含的文件 | 条目无相关文件。 | |||||
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