| New series of 5,6-diphenyl-1, 2,4-triazole-piperazine compound used as anti-tubercular agent against Mycobacterium tuberculosis, where compound is e.g. 4-(benzoylpiperazin-1-yl)-2-(5,6-diphenyl-1,2,4-triazin-3-yl-thia)- ethan-1-one | |
| 2023-11-02 | |
| 专利权人 | PATEL G (PATE-Individual) ; PATEL S I (PATE-Individual) ; PATEL H A (PATE-Individual) ; SHAH M N (SHAH-Individual) ; BHAMRE R S (BHAM-Individual) ; NAGANI A A (NAGA-Individual) ; THAKKAR U J B (THAK-Individual) ; PARUL PHARM PVT LTD (PARU-Non-standard) ; UNIV PARUL PARUL PHARM INST (UYPA-Non-standard) |
| 申请日期 | 2023-11-02 |
| 专利号 | IN202321074739-A |
| 成果简介 | NOVELTY - Series of 5,6-diphenyl-1, 2,4-triazole-piperazine compound (X-XVII) (I), is new, where the compound is selected from 4-(benzoylpiperazin-1-yl)-2-(5,6-diphenyl-1,2,4-triazin-3-yl-thia)- ethan-1-one (X); 1-(4-(4-chlorobenzoyl)piperazin-1-yl)-2-(5,6-diphenyl-1,2,4- triazin-3-yl-thia)ethan-1-one (XI); 2-(5,6-diphenyl-1,2,4-triazin-3-yl-thia)-1-(4-(4- fluoro benzoyl)piperazin-1-yl)ethan-1-one (XII); 1-(4-(4-bromobenzoyl)piperazin-1- yl)-2-(5,6-diphenyl-1,2,4-triazin-3-ylthia)ethan-1-one (XIII); 2-(5,6-diphenyl-1,2,4- triazin-3-yl-thia)-1-(4-(4-nitrobenzoyl)piperazin-1-yl)ethan-1-one (XIV); 2-(5,6- diphenyl-1,2,4-triazin-3-yl-thia)-1-(4-(4-methoxybenzoyl)piperazin-1-yl)ethan-1- one (XV); 1-(4-(2-chlorobenzoyl)piperazin-1-yl)-2-(5,6-diphenyl-1,2,4-triazin-3-yl-thia)ethan-1-one (XVI); and 2-(5,6-diphenyl-1,2,4-triazin-3-yl-thia)-1-(4-(4- methyl benzoyl)piperazin-1-yl)ethan-1-one (XVII). USE - Series of 5,6-diphenyl-1, 2,4-triazole-piperazine compound (I) used as anti-tubercular agent against Mycobacterium tuberculosis. ADVANTAGE - The compound (I) has potent anti-tubercular activity. DETAILED DESCRIPTION - Series of 5,6-diphenyl-1, 2,4-triazole-piperazine compound of formula (X-XVII) (I), is new, where the compound is selected from 4-(benzoylpiperazin-1-yl)-2-(5,6-diphenyl-1,2,4-triazin-3-yl-thia)- ethan-1-one (X); 1-(4-(4-chlorobenzoyl)piperazin-1-yl)-2-(5,6-diphenyl-1,2,4- triazin-3-yl-thia)ethan-1-one (XI); 2-(5,6-diphenyl-1,2,4-triazin-3-yl-thia)-1-(4-(4- fluoro benzoyl)piperazin-1-yl)ethan-1-one (XII); 1-(4-(4-bromobenzoyl)piperazin-1- yl)-2-(5,6-diphenyl-1,2,4-triazin-3-yl-thia)ethan-1-one (XIII); 2-(5,6-diphenyl-1,2,4- triazin-3-yl-thia)-1-(4-(4-nitrobenzoyl)piperazin-1-yl)ethan-1-one (XIV); 2-(5,6- diphenyl-1,2,4-triazin-3-yl-thia)-1-(4-(4-methoxybenzoyl)piperazin-1-yl)ethan-1- one (XV); 1-(4-(2-chlorobenzoyl)piperazin-1-yl)-2-(5,6-diphenyl-1,2,4-triazin-3-yl-thia)ethan-1-one (XVI); and 2-(5,6-diphenyl-1,2,4-triazin-3-yl-thia)-1-(4-(4- methyl benzoyl)piperazin-1-yl)ethan-1-one (XVII), where In the compound (X), X=H; In the compound (XI), X=4-Cl; In the compound (XII), X=4-F; In the compound (XIII), X=4-Br; In the compound (XIV), X=4-NO2; In the compound (XV), X=4-NO2; In the compound (XVI), X=2-Cl; and In the compound (XVII), X=4-CH3. An INDEPENDENT CLAIM is included for a method for series of preparing of the 5,6-diphenyl-1, 2,4-triazole-piperazine compound (I). |
| IPC 分类号 | A01N-043/653 ; A61K-031/4196 ; A61K-031/495 ; C07D-241/00 ; C07D-249/08 ; C07D-295/00 ; C07H-019/056 ; C08G-012/28 |
| 国家 | 印度 |
| 专业领域 | 医药卫生 |
| 语种 | 英语 |
| 成果类型 | 专利 |
| 文献类型 | 科技成果 |
| 条目标识符 | http://119.78.100.226:8889/handle/3KE4DYBR/19364 |
| 专题 | 中国科学院新疆生态与地理研究所 |
| 作者单位 | 1.PATEL G (PATE-Individual) 2.PATEL S I (PATE-Individual) 3.PATEL H A (PATE-Individual) 4.SHAH M N (SHAH-Individual) 5.BHAMRE R S (BHAM-Individual) 6.NAGANI A A (NAGA-Individual) 7.THAKKAR U J B (THAK-Individual) 8.PARUL PHARM PVT LTD (PARU-Non-standard) 9.UNIV PARUL PARUL PHARM INST (UYPA-Non-standard) |
| 推荐引用方式 GB/T 7714 | PATEL G,PATEL S I,PATEL H A,et al. New series of 5,6-diphenyl-1, 2,4-triazole-piperazine compound used as anti-tubercular agent against Mycobacterium tuberculosis, where compound is e.g. 4-(benzoylpiperazin-1-yl)-2-(5,6-diphenyl-1,2,4-triazin-3-yl-thia)- ethan-1-one. IN202321074739-A[P]. 2023. |
| 条目包含的文件 | 条目无相关文件。 | |||||
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